de Sousa Francisco Alves, Correia João Tavares, Ferreira Miguel Gonçalves, Rios Marta, Magalhães Manuel, Santos Mariline
Otorhinolaryngology and Head & Neck Surgery, Centro Hospitalar Universitário de Santo António, Largo do Prof. Abel Salazar, 4099-001, Porto, Portugal.
Head of Sleep Medicine Laboratory, Pediatrics Department of Centro Materno Infantil do Norte, Unidade Local de Saúde de Santo António, Largo do Prof. Abel Salazar, 4099-001, Porto, Portugal.
Eur Arch Otorhinolaryngol. 2025 Feb;282(2):869-879. doi: 10.1007/s00405-024-09093-y. Epub 2024 Dec 2.
Nasal breathing (NB) is a fundamental physiological process, and emerging research indicates its potential role in modulating resting metabolism, impacting energy expenditure and metabolic efficiency. This study investigates the impact of NB on resting metabolic rate (RMR), offering novel insights into metabolic regulation.
A prospective study was conducted on patients undergoing nasal surgery, with measurements taken before and 3 months after surgery. Metabolic rate assessments, anthropometric dimensions, and peak nasal inspiratory flow (PNIF) were recorded. Factors like age, sex, and health status were considered to control for confounding variables.
A total of 83 patients were initially enrolled: 17 underwent septorhinoplasty (SRP), 61 septoplasty (ST) and 5 inferior turbinate reduction alone. 72 patients completed the follow-up. SRP patients exhibited significantly higher pre- and post-operative RMR compared to ST patients (p = 0.005), and this association was not observed when PNIF was included in the analysis (p > 0.05). Pre-operative and post-operative PNIF values significantly correlated with pre-operative and post-operative RMR (p = 0.049 and p = 0.005, respectively). Post-operative PNIF predicted post-operative RMR after confoundment adjustment in linear regression (β = - 0.043, p = 0.017). Importantly, total body weight increased after surgery (pre-op: 74 ± 14.6 kg versus post-op: 75.6 ± 15.5 kg, p < 0.001) due to an increment in muscle mass (pre-op: 52.3 ± 12 versus post-op: 55.5 ± 14, p < 0.01).
Preliminary analysis suggests a potential link between NB and RMR, emphasizing the overlooked role of nasal respiratory physiology in energy homeostasis. Surgery also elicited body composition alterations. Further research is needed to uncover the underlying mechanisms of this association. Understanding the impact of NB on RMR could underscore its significance in metabolic regulation, reinforcing the importance of nasal surgery on overall health. This study provides foundation for future investigations.
鼻腔呼吸（NB）是一种基本的生理过程，新兴研究表明其在调节静息代谢、影响能量消耗和代谢效率方面具有潜在作用。本研究调查了NB对静息代谢率（RMR）的影响，为代谢调节提供了新的见解。
对接受鼻腔手术的患者进行前瞻性研究，在手术前和手术后3个月进行测量。记录代谢率评估、人体测量尺寸和鼻腔最大吸气流量（PNIF）。考虑年龄、性别和健康状况等因素以控制混杂变量。
最初共纳入83例患者：17例行鼻中隔鼻成形术（SRP），61例行鼻中隔成形术（ST），5例仅行下鼻甲切除术。72例患者完成随访。与ST患者相比，SRP患者术前和术后的RMR显著更高（p = 0.005），当分析中纳入PNIF时未观察到这种关联（p > 0.05）。术前和术后的PNIF值与术前和术后的RMR显著相关（分别为p = 0.049和p = 0.005）。在进行线性回归的混杂因素调整后，术后PNIF可预测术后RMR（β = -0.043，p = 0.017）。重要的是，由于肌肉量增加，术后总体体重增加（术前：74 ± 14.6 kg，术后：75.6 ± 15.5 kg，p < 0.001）（术前：52.3 ± 12，术后：55.5 ± 14，p < 0.01）。
初步分析表明NB与RMR之间存在潜在联系，强调了鼻腔呼吸生理在能量稳态中被忽视的作用。手术还引起了身体成分的改变。需要进一步研究以揭示这种关联的潜在机制。了解NB对RMR的影响可能凸显其在代谢调节中的重要性，强化鼻腔手术对整体健康的重要性。本研究为未来的调查提供了基础。
