Louis Gilles, Pétré Benoit, Sousa-Pinto Bernardo, Bousquet Jean, Van Ganse Éric, Schleich Florence, Louis Renaud
Department of Public Health, University of Liège, Liège, Belgium.
Department of Pneumology, GIGAI3, University of Liège, Liège, Belgium.
Sci Rep. 2024 Dec 2;14(1):29997. doi: 10.1038/s41598-024-81745-9.
While studies have demonstrated the impact of asthma symptoms on quality of life, very few studies have investigated the relationship between detailed asthma symptoms, as reported by the patient, and lung function and inflammation. A cross-sectional study was conducted on treated (ICS/LABA) adult (> 18 years) asthma patients recruited from the Liege University Hospital Asthma Clinic (Belgium) between 2018 and 2023 (n = 505). The intensity of asthma symptoms (dyspnea, wheezing, chest tightness, cough, and airway secretion) was measured using five-point Likert scales (5 expressing the greatest intensity). Multiple linear regression models including all independent variables were carried out to evaluate whether lung function and inflammatory parameters were independently associated with distinct symptoms. Cough associated with female gender (p < 0.05), smoking (p < 0.01), low FeNO (p < 0.05) and FEV1% pred. (p < 0.05), and high blood and sputum eosinophils (p < 0.05 for both). Airway secretion associated with smoking (p < 0.05). Chest tightness associated with young age (p < 0.001), female gender (p < 0.05) and low FEV1% pred. (p < 0.01). Dyspnea associated with female gender (p < 0.001), high BMI (p < 0.05), low FEV1% pred. (p < 0.0001) and high FEV1/FVC % (p < 0.01). Wheezing associated with young age (p < 0.01), high BMI (p < 0.05), smoking (p < 0.01), low FEV1% pred. (p < 0.0001) and high FEV1/FVC % (p < 0.05). Different respiratory symptoms are associated with distinct demographic, functional and inflammatory features paving the way for personalized therapeutic interventions.
虽然已有研究证明哮喘症状对生活质量的影响，但很少有研究调查患者报告的详细哮喘症状与肺功能及炎症之间的关系。对2018年至2023年间从列日大学医院哮喘诊所（比利时）招募的接受治疗（吸入糖皮质激素/长效β2受体激动剂）的成年（>18岁）哮喘患者进行了一项横断面研究（n = 505）。使用五点李克特量表测量哮喘症状（呼吸困难、喘息、胸闷、咳嗽和气道分泌物）的强度（5表示强度最大）。进行了包括所有自变量的多元线性回归模型，以评估肺功能和炎症参数是否与不同症状独立相关。咳嗽与女性性别（p < 0.05）、吸烟（p < 0.01）、低呼出一氧化氮（FeNO）（p < 0.05）和预计第一秒用力呼气容积（FEV1%）（p < 0.05）以及高血液和痰液嗜酸性粒细胞（两者均p < 0.05）相关。气道分泌物与吸烟（p < 0.05）相关。胸闷与年轻（p < 0.001）、女性性别（p < 0.05）和低预计FEV1%（p < 0.01）相关。呼吸困难与女性性别（p < 0.001）、高体重指数（BMI）（p < 0.05）、低预计FEV1%（p < 0.0001）和高FEV1/用力肺活量（FVC）%（p < 0.01）相关。喘息与年轻（p < 0.01）、高BMI（p < 0.05）、吸烟（p < 0.01）、低预计FEV1%（p < 0.0001）和高FEV1/FVC %（p < 0.05）相关。不同的呼吸道症状与不同的人口统计学、功能和炎症特征相关，为个性化治疗干预铺平了道路。
