舌下静脉曲张作为心血管疾病相关因素的预测指标：一项系统评价与荟萃分析

Sublingual varices as predictor of factors associated with cardiovascular diseases: A systematic review with meta-analysis.

作者信息

Costa Ana Karolina Leão Silva, de Andrade Ana Claudia Macedo, Felix Fernanda Aragão, Pureza Isabele Rejane de Oliveira Maranhão, Nóbrega Diego Figueiredo, de França Glória Maria

机构信息

Centro Universitário CESMAC, Maceió, Alagoas, Brazil.

School of Dentistry, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, RM, Chile.

出版信息

Oral Maxillofac Surg. 2024 Dec 3;29(1):15. doi: 10.1007/s10006-024-01311-5.

DOI:10.1007/s10006-024-01311-5

PMID:39623150

Abstract

OBJECTIVE

Sublingual varicose veins are variations of normality that appear more prominent during aging. The systematic review aim to investigate sublingual varicose veins frequency in patients exposed to systemic and environmental exposed factors linked to cardiovascular diseases.

METHODS

This systematic review was based on the PECO strategy, and the PubMed, Web of Science, Scopus, Embase and Grey Literature library were searched for publications examining the association between sublingual varicose veins and systemic and environmental exposed factors linked to cardiovascular diseases, such as hypertension, diabetes, smoking, and leg varices. A meta-analysis was conducted using random-effects models. This review included 11 studies with a total of 2,272 patients with sublingual varicosity and systemic exposed factors linked to cardiovascular diseases. The quality assessment was improved by Newcastle and Ottawa Scales (NOS).

RESULTS

Consistent results were observed across all systemic and environmental exposed factors linked to cardiovascular diseases subgroups. We found association between sublingual varicose veins and hypertension [p = 0.0002; 95%IC2.90 [1.66-5.06]; I 91%); diabetics (p = 0.009; 95%IC 3.19 [1.34 - 7.62]; I 84%); tobacco abuse (p = 0.002; 95%IC 1.97 [1.29 - 3.01]; I 82%) and leg varicosity (p = 0.03; 95%IC 2.63 [1.08 - 6.44]; I 95%). Seven articles received score 7, indicating good quality and four articles received moderate quality.

CONCLUSION

Patients exposed to exposed factors that affect blood vessels showed a higher prevalence of sublingual varicose veins. These findings emphasize the importance of recognizing oral signs underlying systemic diseases.

SYSTEMATIC REVIEW REGISTRATION

PROSPERO CRD42023397166.

摘要

目的

舌下静脉曲张是一种正常变异，在衰老过程中更为明显。本系统评价旨在调查暴露于与心血管疾病相关的全身和环境暴露因素的患者中舌下静脉曲张的发生率。

方法

本系统评价基于PECO策略，检索了PubMed、科学网、Scopus、Embase和灰色文献库，以查找研究舌下静脉曲张与与心血管疾病相关的全身和环境暴露因素（如高血压、糖尿病、吸烟和下肢静脉曲张）之间关联的出版物。使用随机效应模型进行荟萃分析。本评价纳入了11项研究，共有2272例患有舌下静脉曲张和与心血管疾病相关的全身暴露因素的患者。采用纽卡斯尔和渥太华量表（NOS）进行质量评估。

结果

在与心血管疾病亚组相关的所有全身和环境暴露因素中均观察到一致的结果。我们发现舌下静脉曲张与高血压之间存在关联[p = 0.0002；95%置信区间2.90 [1.66 - 5.06]；I² 91%]；糖尿病患者（p = 0.009；95%置信区间3.19 [1.34 - 7.62]；I² 84%）；烟草滥用（p = 0.002；95%置信区间1.97 [1.29 - 3.01]；I² 82%）和下肢静脉曲张（p = 0.03；95%置信区间2.63 [1.08 - 6.44]；I² 95%）。七篇文章得分为7分，表明质量良好，四篇文章质量中等。