Wang Muyao, Chihchieh Lo, Hou Min, Liu Shuo, Zhang Yan, Wang Hang
Department of Plastic Surgery, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin, 300041, China.
Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction, Tianjin, 300041, China.
Aesthetic Plast Surg. 2024 Dec 2. doi: 10.1007/s00266-024-04543-8.
For decades, a diverse range of natural and synthetic materials have been utilized to enhance human tissue and achieve improved aesthetic results. Among these, dermal fillers are some of the most popular treatments. Initially, the primary role of dermal fillers was to restore lost volume. However, with advancements in biomaterial research, a variety of biostimulatory fillers have become essential in aesthetic medicine. One such filler, polylactic acid (PLA), has been extensively used for facial rejuvenation. Upon injection, PLA not only provides immediate volume restoration but also enhances skin quality and appearance while promoting the regeneration of collagen, elastin, and vasculature. This narrative review highlights PLA as a regenerative aesthetic treatment, detailing its physicochemical properties, mechanisms of regeneration stimulation, and clinical applications in facial aesthetics. It represents the cutting-edge foundation upon which further developments can be built to ensure optimal and safe outcomes in treatments using PLA-based collagen stimulators and other similar products for facial rejuvenation. LEVEL OF EVIDENCE V: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
几十年来，各种各样的天然和合成材料被用于改善人体组织并实现更好的美学效果。其中，真皮填充剂是一些最受欢迎的治疗方法。最初，真皮填充剂的主要作用是恢复流失的容积。然而，随着生物材料研究的进展，多种生物刺激填充剂在美容医学中变得至关重要。一种这样的填充剂，聚乳酸（PLA），已被广泛用于面部年轻化。注射后，PLA不仅能立即恢复容积，还能改善皮肤质量和外观，同时促进胶原蛋白、弹性蛋白和血管的再生。这篇叙述性综述强调PLA作为一种再生性美容治疗方法，详细阐述其物理化学性质、再生刺激机制以及在面部美学中的临床应用。它代表了一个前沿基础，在此基础上可以进一步发展，以确保在使用基于PLA的胶原蛋白刺激剂和其他类似产品进行面部年轻化治疗时能获得最佳和安全的效果。证据级别V：本刊要求作者为每篇文章指定证据级别。有关这些循证医学评级的完整描述，请参阅目录或在线作者指南www.springer.com/00266 。
