Li Qiqiang
General Practice Department, Fuyong People's Hospital of Baoan District, Shenzhen, 518103, China.
Eur J Med Res. 2024 Dec 3;29(1):575. doi: 10.1186/s40001-024-02174-y.
The risks of obesity and epigenetic age acceleration (EAA) have drawn widespread attention. Lipid accumulation product (LAP) is a simple and reliable indicator of obesity; however, the relationship between LAP and EAA remains unclear.
Data from the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2002 were used. The EAA was assessed using a self-administered questionnaire in the database. LAP was calculated based on triglycerides and waist circumference. The association between LAP and EAA was analyzed using logistic regression models, subgroup analysis, and smooth curve fitting.
A total of 1796 participants were included in the study, of whom 1055 had EAA. After adjusting for relevant covariates, participants with EAA generally had higher LAP levels than those without EAA (258.1 vs. 244.6). Logistic regression analysis showed that individuals in the highest LAP quartile (Q4) were more likely to have EAA than those in the lowest quartile (Q1) (OR = 1.77; 95% CI 1.31-2.39; P < 0.001). The area under the curve of the adjusted logistic regression analysis was 0.706.
This research indicates that elevated LAP levels are independently linked to an increased risk of EAA, and early intervention to reduce high LAP levels is necessary to mitigate the progression of EAA.
肥胖风险和表观遗传年龄加速（EAA）已引起广泛关注。脂质蓄积产物（LAP）是一种简单可靠的肥胖指标；然而，LAP与EAA之间的关系仍不明确。
使用1999年至2002年美国国家健康与营养检查调查（NHANES）的数据。通过数据库中的一份自填式问卷评估EAA。根据甘油三酯和腰围计算LAP。使用逻辑回归模型、亚组分析和平滑曲线拟合分析LAP与EAA之间的关联。
该研究共纳入1796名参与者，其中1055人有EAA。在调整相关协变量后，有EAA的参与者的LAP水平总体上高于无EAA的参与者（258.1对244.6）。逻辑回归分析表明，LAP四分位数最高（Q4）的个体比四分位数最低（Q1）的个体更有可能有EAA（比值比=1.77；95%置信区间1.31-2.39；P<0.001）。调整后的逻辑回归分析的曲线下面积为0.706。
本研究表明，LAP水平升高与EAA风险增加独立相关，早期干预以降低高LAP水平对于减缓EAA进展是必要的。
