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Integration of single-cell and bulk RNA sequencing unravels metalloendopeptidase+ neutrophils as key inflammatory drivers in abdominal aortic aneurysm.

作者信息

Yuan Lushun, Liang Chuan, Cheng Shuzhen, Zhou Jianliang, Chen Song

机构信息

Department of Vascular Surgery, Intervention Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Department of Cardiovascular Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China.

出版信息

Clin Transl Med. 2024 Dec;14(12):e70121. doi: 10.1002/ctm2.70121.

DOI:10.1002/ctm2.70121
PMID:39623871
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11612259/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2973/11612259/20c6f88acc38/CTM2-14-e70121-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2973/11612259/5a8bcb27a213/CTM2-14-e70121-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2973/11612259/2b7aa75c20c9/CTM2-14-e70121-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2973/11612259/06e858e762c3/CTM2-14-e70121-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2973/11612259/20c6f88acc38/CTM2-14-e70121-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2973/11612259/5a8bcb27a213/CTM2-14-e70121-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2973/11612259/2b7aa75c20c9/CTM2-14-e70121-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2973/11612259/06e858e762c3/CTM2-14-e70121-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2973/11612259/20c6f88acc38/CTM2-14-e70121-g004.jpg

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本文引用的文献

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The Role of Immune Mechanisms in Abdominal Aortic Aneurysm: Could It be a Promising Therapeutic Strategy?免疫机制在腹主动脉瘤中的作用：它会是一种有前景的治疗策略吗？
Acta Cardiol Sin. 2023 Sep;39(5):675-686. doi: 10.6515/ACS.202309_39(5).20230531A.
2
Pathogenesis and management of abdominal aortic aneurysm.腹主动脉瘤的发病机制与处理。
Eur Heart J. 2023 Aug 1;44(29):2682-2697. doi: 10.1093/eurheartj/ehad386.
3
Identification of core cuprotosis-correlated biomarkers in abdominal aortic aneurysm immune microenvironment based on bioinformatics.
基于生物信息学的腹主动脉瘤免疫微环境中核心铜死亡相关生物标志物的鉴定。
Front Immunol. 2023 Apr 17;14:1138126. doi: 10.3389/fimmu.2023.1138126. eCollection 2023.
4
Immune and inflammatory mechanisms of abdominal aortic aneurysm.腹主动脉瘤的免疫和炎症机制。
Front Immunol. 2022 Oct 5;13:989933. doi: 10.3389/fimmu.2022.989933. eCollection 2022.
5
Single-cell Transcriptomics Reveals Dynamic Role of Smooth Muscle Cells and Enrichment of Immune Cell Subsets in Human Abdominal Aortic Aneurysms.单细胞转录组学揭示了人类腹主动脉瘤中平滑肌细胞的动态作用和免疫细胞亚群的富集。
Ann Surg. 2022 Sep 1;276(3):511-521. doi: 10.1097/SLA.0000000000005551. Epub 2022 Jun 28.
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Single-Cell RNA Sequencing Technology Revealed the Pivotal Role of Fibroblast Heterogeneity in Angiotensin II-Induced Abdominal Aortic Aneurysms.单细胞RNA测序技术揭示了成纤维细胞异质性在血管紧张素II诱导的腹主动脉瘤中的关键作用。
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