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腭隆突骨坏死:长期使用地诺单抗迄今未报道的并发症。

Torus palatinus osteonecrosis: A hitherto unreported complication of long-term Denosumab use.

作者信息

Weger Kendal L, Archang Maani M, Lo Ying-Chun, Yin Linda X, Armstrong Michael F, Guerin Julie B, Mark Ian T, Benson John C

机构信息

Mayo Clinic, Department of Radiology, 200 1st Street SW, Rochester, MN, USA.

出版信息

Radiol Case Rep. 2024 Nov 14;20(1):772-776. doi: 10.1016/j.radcr.2024.10.082. eCollection 2025 Jan.

Abstract

Torus palatinus is an osseus exostosis found in the midline of the hard palate. It is a relatively common condition and is benign in nearly all cases. However, complications such as airway obstruction, sleep apnea, and swallowing difficulties do exist. One of the more serious complications is osteonecrosis. Osteonecrosis of tori has scantly been reported in the literature. Reported risk factors include bisphosphonate use, trauma, and anticoagulation. Here, we present a case of torus palatinus osteonecrosis in the setting of Denosumab use, a monoclonal antibody for the treatment of osteoporosis. This case brings awareness to a rare, but important, potential complication of long-term use of that medication.

摘要

腭隆突是位于硬腭中线的骨性外生骨疣。它是一种相对常见的病症,几乎在所有病例中都是良性的。然而,确实存在诸如气道阻塞、睡眠呼吸暂停和吞咽困难等并发症。较严重的并发症之一是骨坏死。文献中很少报道腭隆突的骨坏死。报道的危险因素包括使用双膦酸盐、创伤和抗凝治疗。在此,我们报告一例在使用地诺单抗(一种用于治疗骨质疏松症的单克隆抗体)的情况下发生腭隆突骨坏死的病例。该病例使人们认识到长期使用该药物一种罕见但重要的潜在并发症。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a00/11609110/9affe25ef6d9/gr1.jpg

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