Claudin-4通过核和细胞周期重塑稳定基因组以支持卵巢癌细胞存活。

Claudin-4 Stabilizes the Genome via Nuclear and Cell-Cycle Remodeling to Support Ovarian Cancer Cell Survival.

作者信息

Villagomez Fabian R, Lang Julie, Nunez-Avellaneda Daniel, Behbakht Kian, Dimmick Hannah L, Webb Patricia G, Nephew Kenneth P, Neville Margaret, Woodruff Elizabeth R, Bitler Benjamin G

机构信息

Division of Reproductive Sciences, Department of Obstetrics and Gynecology, School of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, Colorado.

Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, Colorado.

出版信息

Cancer Res Commun. 2025 Jan 1;5(1):39-53. doi: 10.1158/2767-9764.CRC-24-0558.

High-grade serous ovarian carcinoma is marked by chromosomal instability, which can serve to promote disease progression and allow cancer to evade therapeutic insults. The report highlights the role of claudin-4 in regulating genomic instability and proposes a novel therapeutic approach to exploit claudin-4-mediated regulation.