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以难治性高钠血症为表现的颅内叶性生殖细胞瘤。

Intracranial lobar germinoma presenting with refractory hypernatremia.

作者信息

Sipani Mahak, Birua Gyani Jail Singh, Shashidhar Abhinith, Arivazhagan A, Rao Shilpa, Saini Jitender

机构信息

Department of Neurosurgery, Neuro-Center Building, National Institute of Mental Health & Neurosciences (NIMHANS), 29, Bengaluru, Karnataka, 560029, India.

Department of Neuropathology, National Institute of Mental Health & Neurosciences (NIMHANS), 29, Bengaluru, Karnataka, 560029, India.

出版信息

Childs Nerv Syst. 2024 Dec 3;41(1):30. doi: 10.1007/s00381-024-06675-3.

DOI:10.1007/s00381-024-06675-3
PMID:39625527
Abstract

Central nervous system germ cell tumours are most commonly seen in the midline structures. Eccentric germinomas are rare but can be found in the basal ganglia, lobar, brainstem, and cranial vault. We present a 14-year-old boy who presented with signs and symptoms of overt diabetes insipidus and a radiological diagnosis of left frontal high-grade glioma. Confirmative histopathology revealed germinoma. The patient had a resolution of hypernatremia post-surgery and maintained normal sodium homeostasis on a single dose of 0.1 mg of tablet desmopressin. This paper showcases a rare case of an eccentric central nervous system germinoma in a young male patient presenting with Diabetes Insipidus without any apparent sellar or suprasellar involvement.

摘要

中枢神经系统生殖细胞肿瘤最常见于中线结构。偏心性生殖细胞瘤很少见,但可发生于基底神经节、脑叶、脑干和颅顶。我们报告一名14岁男孩,他出现明显尿崩症的体征和症状,影像学诊断为左额叶高级别胶质瘤。确诊的组织病理学检查显示为生殖细胞瘤。患者术后高钠血症得到缓解,单剂量服用0.1毫克去氨加压素片后钠稳态维持正常。本文展示了一例年轻男性患者罕见的偏心性中枢神经系统生殖细胞瘤病例,该患者表现为尿崩症,且无明显鞍区或鞍上受累。

相似文献

1
Intracranial lobar germinoma presenting with refractory hypernatremia.以难治性高钠血症为表现的颅内叶性生殖细胞瘤。
Childs Nerv Syst. 2024 Dec 3;41(1):30. doi: 10.1007/s00381-024-06675-3.
2
[Marked hypernatremia in suprasellar germinoma lacking a sense of thirst].[鞍上生殖细胞瘤中存在明显高钠血症但无口渴感]
Nihon Jinzo Gakkai Shi. 1999 Dec;41(8):804-12.
3
Adipsic diabetes insipidus revealing a bifocal intracranial germinoma.无渴感的尿崩症揭示了一例双灶性颅内生殖细胞瘤。
Ann Endocrinol (Paris). 2017 Jul;78(3):141-145. doi: 10.1016/j.ando.2016.10.005. Epub 2017 May 5.
4
Intracranial Germinoma Misdiagnosed as Hyperthyroidism: A Case Report and Review of the Literature.颅内生殖细胞瘤误诊为甲亢:病例报告及文献复习。
Front Endocrinol (Lausanne). 2022 Jan 24;12:789109. doi: 10.3389/fendo.2021.789109. eCollection 2021.
5
Unusual presentation of epilepsy of germinoma located in the frontal-lobe: case report and literature review.位于额叶的生殖细胞瘤性癫痫的不典型表现:病例报告及文献复习。
Br J Neurosurg. 2022 Apr;36(2):274-276. doi: 10.1080/02688697.2018.1523367. Epub 2018 Nov 19.
6
Suprasellar germinoma associated with Cushing's disease and diabetes insipidus in a child.一名儿童鞍上生殖细胞瘤合并库欣病和尿崩症
Pediatr Neurosurg. 1998 Jul;29(1):19-22. doi: 10.1159/000028679.
7
Suprasellar cystic germinoma.鞍上囊性生殖细胞瘤。
Childs Nerv Syst. 1999 Mar;15(2-3):134-6. doi: 10.1007/s003810050351.
8
Case study: suprasellar germinoma presenting with psychotic and obsessive-compulsive symptoms.
J Am Acad Child Adolesc Psychiatry. 2000 Jan;39(1):116-9. doi: 10.1097/00004583-200001000-00024.
9
[Germinoma: a rare cerebral tumor causing central diabetes insipidus in childhood].[生殖细胞瘤:一种导致儿童中枢性尿崩症的罕见脑肿瘤]
Minerva Pediatr. 2008 Feb;60(1):129-33.
10
CNS germinomas: curable tumours in two adolescents.中枢神经系统生殖细胞瘤:两名青少年可治愈的肿瘤
J Paediatr Child Health. 1994 Feb;30(1):68-71. doi: 10.1111/j.1440-1754.1994.tb00570.x.

本文引用的文献

1
Intracranial germinoma in the lateral ventricle with polydipsia and polyuria: a case report and literature review.侧脑室内颅内生殖细胞瘤伴多饮多尿:一例病例报告并文献复习。
Childs Nerv Syst. 2023 Apr;39(4):1065-1069. doi: 10.1007/s00381-022-05711-4. Epub 2022 Oct 22.
2
Phase II trial of response-based radiation therapy for patients with localized germinoma: a Children's Oncology Group study.局限性生殖细胞瘤患者基于反应的放射治疗II期试验:一项儿童肿瘤学组研究
Neuro Oncol. 2022 Jun 1;24(6):974-983. doi: 10.1093/neuonc/noab270.
3
Primary Germinoma Originating from the Insular Lobe: A Case Report and Review of the Literature.
起源于岛叶的原发性生殖细胞瘤:一例报告并文献复习
World Neurosurg. 2017 Feb;98:871.e1-871.e7. doi: 10.1016/j.wneu.2016.12.004. Epub 2016 Dec 19.
4
Primary intracranial germ cell tumors: a clinical analysis of 153 histologically verified cases.原发性颅内生殖细胞肿瘤:153例组织学确诊病例的临床分析
J Neurosurg. 1997 Mar;86(3):446-55. doi: 10.3171/jns.1997.86.3.0446.