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以难治性高钠血症为表现的颅内叶性生殖细胞瘤。

Intracranial lobar germinoma presenting with refractory hypernatremia.

作者信息

Sipani Mahak, Birua Gyani Jail Singh, Shashidhar Abhinith, Arivazhagan A, Rao Shilpa, Saini Jitender

机构信息

Department of Neurosurgery, Neuro-Center Building, National Institute of Mental Health & Neurosciences (NIMHANS), 29, Bengaluru, Karnataka, 560029, India.

Department of Neuropathology, National Institute of Mental Health & Neurosciences (NIMHANS), 29, Bengaluru, Karnataka, 560029, India.

出版信息

Childs Nerv Syst. 2024 Dec 3;41(1):30. doi: 10.1007/s00381-024-06675-3.

Abstract

Central nervous system germ cell tumours are most commonly seen in the midline structures. Eccentric germinomas are rare but can be found in the basal ganglia, lobar, brainstem, and cranial vault. We present a 14-year-old boy who presented with signs and symptoms of overt diabetes insipidus and a radiological diagnosis of left frontal high-grade glioma. Confirmative histopathology revealed germinoma. The patient had a resolution of hypernatremia post-surgery and maintained normal sodium homeostasis on a single dose of 0.1 mg of tablet desmopressin. This paper showcases a rare case of an eccentric central nervous system germinoma in a young male patient presenting with Diabetes Insipidus without any apparent sellar or suprasellar involvement.

摘要

中枢神经系统生殖细胞肿瘤最常见于中线结构。偏心性生殖细胞瘤很少见,但可发生于基底神经节、脑叶、脑干和颅顶。我们报告一名14岁男孩,他出现明显尿崩症的体征和症状,影像学诊断为左额叶高级别胶质瘤。确诊的组织病理学检查显示为生殖细胞瘤。患者术后高钠血症得到缓解,单剂量服用0.1毫克去氨加压素片后钠稳态维持正常。本文展示了一例年轻男性患者罕见的偏心性中枢神经系统生殖细胞瘤病例,该患者表现为尿崩症,且无明显鞍区或鞍上受累。

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