Jin Zhenlan, Li Simeng, Wang Changan, Chai Xiaoqian, Zhang Junjun, Li Ling
MOE Key Lab for Neuroinformation, The Clinical Hospital of Chengdu Brain Science Institute, University of Electronic Science and Technology of China, Chengdu, China.
Department of Neurology and Neurosurgery, McGill University, Montreal, QC, H3A 2B4, Canada.
Brain Topogr. 2024 Dec 3;38(1):18. doi: 10.1007/s10548-024-01094-8.
Human beings exhibit varying risk-taking behaviors in response to different risk levels. Despite numerous studies on risk-taking in decision-making, the neural mechanisms of decision-making regarding risk levels remains unclear. To investigate the neural correlates of individual differences in risk-taking under different risk-levels, we analyzed behavioral data of the Balloon Analogue Risk Task (BART) and resting-state functional Magnetic Resonance Imaging (rs-fMRI) data of healthy participants (22-39 years, N = 93) from the University of California, Los Angeles Consortium for Neuropsychiatric Phenomics dataset. In the BART, the participants decided to pump for more points or stop pumping to avoid explosion of the balloons, where the risk level was manipulated by the explosion likelihood which was distinguished by the balloon color (blue for low-, red for high- risk condition). Compared with low-risk condition, the participants pumped less number, exploded more balloons, and showed more variability in pump numbers in high-risk condition, demonstrating the effective manipulation of the risky level. Next, resting state features and functional connectivity (rsFC) strength were associated with behavioral measures in low- and high-risk conditions. We found that the explosion number of balloons were correlated with the low frequency fluctuations (ALFF) in the left dorsolateral prefrontal cortex (L. DLPFC), the rsFC strength between L. DLPFC and the left anterior orbital gyrus in the low-risk condition. In the high-risk condition, we found variability in pump numbers was correlated with the ALFF in the left middle/superior frontal gyrus, the fractional ALFF (fALFF) in the medial segment of precentral gyrus (M. PrG), and the rsFC strength between the M. PrG and bilateral precentral gyrus. Our results highlighted significance of the L. DLPFC in lower risky decision making and the precentral gyrus in higher risky decision making, suggesting that distinctive neural correlates underlie the individual differences of decision-making under different risk level.
人类在面对不同风险水平时会表现出不同的冒险行为。尽管对决策中的冒险行为进行了大量研究，但关于风险水平决策的神经机制仍不清楚。为了研究不同风险水平下冒险行为个体差异的神经关联，我们分析了来自加州大学洛杉矶分校神经精神疾病基因组学联盟数据集的健康参与者（22 - 39岁，N = 93）的气球模拟风险任务（BART）行为数据和静息态功能磁共振成像（rs - fMRI）数据。在BART中，参与者决定为获得更多分数而打气或停止打气以避免气球爆炸，其中风险水平由气球颜色区分的爆炸可能性来操纵（蓝色代表低风险条件，红色代表高风险条件）。与低风险条件相比，参与者在高风险条件下打气次数更少，气球爆炸更多，且打气次数的变异性更大，表明风险水平得到了有效操纵。接下来，静息态特征和功能连接（rsFC）强度与低风险和高风险条件下的行为指标相关联。我们发现，在低风险条件下，气球爆炸次数与左侧背外侧前额叶皮层（L. DLPFC）的低频波动（ALFF）以及L. DLPFC与左侧眶前回之间的rsFC强度相关。在高风险条件下，我们发现打气次数的变异性与左侧额中/上回的ALFF、中央前回内侧段（M. PrG）的分数ALFF（fALFF）以及M. PrG与双侧中央前回之间的rsFC强度相关。我们的结果强调了L. DLPFC在低风险决策中的重要性以及中央前回在高风险决策中的重要性，表明不同的神经关联是不同风险水平下决策个体差异的基础。
