异常的克鲁格严格形态与精子DNA碎片化指数之间的相关性。
The correlation between abnormal Krüger strict morphology and the sperm DNA fragmentation index.
作者信息
Ranzato Tamyres Souza Garcia Alvim, Mello Mariana Duque de, Souza Paula Fontoura Coelho de, Farias Lincoln Bastos, Araujo Luiz Felipe Bittencourt de, Penna Ivan Andrade de Araujo
机构信息
Fluminense Federal University Niterói, RJ, Brazil.
Sperm Bank of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
出版信息
JBRA Assist Reprod. 2024 Dec 2;28(4):618-623. doi: 10.5935/1518-0557.20240068.
OBJECTIVE
This study aims to investigate whether alterations in sperm DNA fragmentation rates are more frequent when Krüger strict morphology is ≥4% (normal).
METHODS
The retrospective study included 132 participants from March 2020 to November 2021. Participants were divided into two groups based on the inclusion criteria: normal and abnormal Krüger strict morphology, with a mean age of 40 years. Seminal analyses were conducted following the guidelines outlined in the 6th edition of the Manual for Examination and Processing of Human Semen (2021). The sperm chromatin dispersion test was used.
RESULTS
The results did not reveal a statistically significant difference between Krüger strict morphology and Sperm DNA Fragmentation Index correlation (p<0.05) between the normal and abnormal morphology groups (p<0.05) and in Seminal Parameters. Sperm concentration is lower when Krüger strict morphology is < 4% (abnormal) (p=0.007).
CONCLUSIONS
In conclusion, abnormal Krüger strict morphology does not have a higher predisposition to increased sperm DNA fragmentation.
目的
本研究旨在调查当克鲁格严格形态学标准≥4%（正常）时，精子DNA碎片化率的改变是否更频繁。
方法
这项回顾性研究纳入了2020年3月至2021年11月的132名参与者。根据纳入标准将参与者分为两组：克鲁格严格形态学正常组和异常组，平均年龄为40岁。精液分析按照《人类精液检查与处理手册》第6版（2021年）所述指南进行。采用精子染色质扩散试验。
结果
结果显示，正常形态组与异常形态组之间，克鲁格严格形态学与精子DNA碎片化指数的相关性（p<0.05）以及精液参数方面，均未发现统计学上的显著差异。当克鲁格严格形态学<4%（异常）时，精子浓度较低（p=0.007）。
结论
总之，克鲁格严格形态学异常并不会使精子DNA碎片化增加的易感性更高。
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