不同年龄的正常个体及IgG亚类缺陷个体中不同免疫球蛋白亚类的肺炎球菌抗体

Pneumococcal antibodies of different immunoglobulin subclasses in normal and IgG subclass deficient individuals of various ages.

作者信息

Rynnel-Dagöö B, Freijd A, Hammarström L, Oxelius V, Persson M A, Smith C I

出版信息

Acta Otolaryngol. 1986 Jan-Feb;101(1-2):146-51. doi: 10.3109/00016488609108617.

Abstract

The distribution of pneumococcal antibody activity of the IgG and IgA subclasses was determined in healthy individuals of various ages using monoclonal antibodies in an enzyme linked immunosorbent assay (ELISA). High IgG 2 antibody activity was found in cord blood and in serum from adults. IgG 1 activity was most pronounced in serum from young children and virtually lacking in serum from adults. Anti-pneumococcal antibodies were found to be low in IgG 2 deficient donors and normal in IgG 3 deficient donors. A maturation from relatively low IgG 1 and IgG 2 antipneumococcal activity in young children to high IgG 2 levels in adults was found in healthy individuals. IgA subclass antipneumococcal activity was correlated to age. Evaluation of the distribution of pneumococcal antibody activity of various subclasses offers a new possibility for studying the immune response to infection and immunization.

摘要

在酶联免疫吸附测定（ELISA）中使用单克隆抗体，测定了不同年龄健康个体中肺炎球菌抗体活性的IgG和IgA亚类分布。在脐血和成人血清中发现高IgG 2抗体活性。IgG 1活性在幼儿血清中最为明显，而在成人血清中几乎不存在。在IgG 2缺陷供体中发现抗肺炎球菌抗体较低，而在IgG 3缺陷供体中正常。在健康个体中发现，幼儿相对较低的IgG 1和IgG 2抗肺炎球菌活性向成人中高IgG 2水平成熟。IgA亚类抗肺炎球菌活性与年龄相关。评估各种亚类肺炎球菌抗体活性的分布为研究对感染和免疫的免疫反应提供了新的可能性。