HIV感染和未感染的结核病患者对分枝杆菌脂阿拉伯甘露聚糖的免疫球蛋白G亚类反应。
Immunoglobulin G subclass responses to mycobacterial lipoarabinomannan in HIV-infected and non-infected patients with tuberculosis.
作者信息
Da Costa C T, Khanolkar-Young S, Elliott A M, Wasunna K M, McAdam K P
机构信息
Department of Clinical Sciences, London School of Hygiene & Tropical Medicine, UK.
出版信息
Clin Exp Immunol. 1993 Jan;91(1):25-9. doi: 10.1111/j.1365-2249.1993.tb03348.x.
Abstract
Immunoglobulin G subclass responses to lipoarabinomannan (LAM) of Mycobacterium tuberculosis were determined by ELISA in both HIV-1 antibody positive (n = 31) and negative (n = 43) patients with tuberculosis (TB). Responses were also studied in a group of healthy controls (n = 16) and HIV-1 antibody positive (n = 60) individuals without TB. IgG2 antibodies were the predominant subclass, being present in 25 of 43 non-HIV-infected TB patients (58%) and in 11 of 31 HIV-infected TB patients (35%). However, HIV+ TB patients also showed IgG4 (n = 16; 52%), and IgG1 (n = 4, 13%) responses to LAM, whereas these subclasses were absent in sera from HIV-TB patients. Individuals in both non-tuberculous control groups showed no antibody responses to LAM. The influence of HIV infection on B cell responses to LAM, and possible mechanisms for antibody-mediated regulation of immunity to TB, are explored.
摘要
采用酶联免疫吸附测定法（ELISA），对31例HIV-1抗体阳性和43例HIV-1抗体阴性的结核病（TB）患者针对结核分枝杆菌脂阿拉伯甘露聚糖（LAM）的免疫球蛋白G亚类反应进行了测定。还对一组健康对照者（n = 16）和60例无结核病的HIV-1抗体阳性个体进行了反应研究。IgG2抗体是主要亚类，在43例未感染HIV的结核病患者中有25例（58%）出现，在31例感染HIV的结核病患者中有11例（35%）出现。然而，HIV阳性结核病患者对LAM还表现出IgG4反应（n = 16；52%）和IgG1反应（n = 4，13%），而在未感染HIV的结核病患者血清中未出现这些亚类反应。两个非结核对照组个体对LAM均无抗体反应。本文探讨了HIV感染对B细胞针对LAM反应的影响，以及抗体介导的结核病免疫调节的可能机制。
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