一项基于全国人群队列研究中胃食管反流病与耳鸣之间的关联
Association between gastroesophageal reflux disease and tinnitus in a nationwide population-based cohort study.
作者信息
Kang Sung-Woo, An Min Ho, Ha Seojung, Kim Min-Gyu, Park Tae Jun, Kim Han Ki, Sheen Kisung, Park Rae Woong, Park Soon Sang
机构信息
Department of Internal Medicine, Kyung Hee University College of Korean Medicine, Seoul, 02447, Korea.
Department of Biomedical Informatics, Ajou University School of Medicine, Suwon, 16499, Korea.
出版信息
Sci Rep. 2024 Dec 3;14(1):30106. doi: 10.1038/s41598-024-81658-7.
Gastroesophageal Reflux Disease (GERD) is characterized by the regurgitation of stomach contents. Recent research indicates that acid reflux may disrupt the homeostasis of the middle and inner ear through the Eustachian tube. Given this context, we hypothesized that an association between GERD and tinnitus may exist due to the imbalance of the middle and inner ear caused by acid reflux. To explore this connection, we conducted a retrospective cohort study involving 669,159 patients registered in the National Health Insurance Service-National Sample Cohort (2012-2019) in South Korea. Our data showed that GERD and tinnitus are highly associated. Nevertheless, the use of proton pump inhibitor medication in GERD patients did not show a significant decrease in the onset of tinnitus.
胃食管反流病（GERD）的特征是胃内容物反流。最近的研究表明，胃酸反流可能通过咽鼓管破坏中耳和内耳的内环境稳态。鉴于此，我们推测，由于胃酸反流导致的中耳和内耳失衡，GERD与耳鸣之间可能存在关联。为了探究这种联系，我们进行了一项回顾性队列研究，研究对象为韩国国家健康保险服务-国家样本队列（2012-2019年）中登记的669159名患者。我们的数据显示，GERD与耳鸣高度相关。然而，GERD患者使用质子泵抑制剂药物并未显著降低耳鸣的发病率。
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