美国成年人血清铁状态与结直肠癌风险之间的关联：2001 - 2020年美国国家健康与营养检查调查（NHANES）的横断面分析
Association between serum iron status and the risk of colorectal cancer in US adults: a cross-sectional analysis of NHANES 2001-2020.
作者信息
Zhou Menghua, Shao Yanfei, Chen Weiwei, Guan Bingjie, Xie Bowen, Liu Youdong, Gu Qi, Zhou Mantang, Peng Daliang, Li Feng, Wang Yongtai, Zhang Sen, Yan Dongwang
机构信息
Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 100 Haining Road, Shanghai, 200080, China.
Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
出版信息
BMC Gastroenterol. 2024 Dec 3;24(1):449. doi: 10.1186/s12876-024-03540-0.
BACKGROUND
Maintaining iron homeostasis is crucial for preventing the development of colorectal cancer (CRC). However, Evidence regarding the correlation between serum iron status and CRC has been inconsistent. This population-based study aims to explore the potential association between serum iron status and CRC risk.
METHODS
Using data from the National Health and Nutrition Examination Survey (NHANES) registry spanning from 2001 to 2020, a cross-sectional study involving 9504 participants was performed to assess the relationship between serum iron status and CRC risk. The study encompassed men and women of various racial backgrounds, aged 20 to 80, from across the United States. Participants' characteristics were presented using mean or proportion. The possible risk factor for CRC was examined using both univariable and multivariable analysis. A logistic regression model was used to estimate the odds ratios (ORs) and 95% confidence intervals (CIs) of CRC in accordance with each quantile increment in serum iron item levels.
RESULTS
After making full adjustment, our analysis did not reveal a statistically significant association between serum iron, ferritin, transferrin saturation (TSAT), total iron-binding capacity (TIBC) and the risk of CRC. While there was no statistically significant difference observed, an increasing ferritin concentration appeared to be associated with a decreased CRC risk when compared to the lowest quantile. Specifically, the ORs and 95% CIs for the second, third, and fourth quantiles (Q2, Q3, and Q4) versus the lowest quantile (Q1) were as follows: Q2 (vs. Q1) OR 0.403, 95% CI 0.063-2.568; Q3 (vs. Q1) OR 0.316, 95% CI 0.059-1.687; Q4 (vs. Q1) OR 0.250, 95% CI 0.050-1.258. However, this trend did not reach statistical significance (P for trend = 0.381).
CONCLUSION
Our analyze did not demonstrate a statistically significant correlation between serum iron status and the risk of CRC.
背景
维持铁稳态对于预防结直肠癌（CRC）的发生至关重要。然而，关于血清铁状态与CRC之间相关性的证据并不一致。这项基于人群的研究旨在探讨血清铁状态与CRC风险之间的潜在关联。
方法
利用2001年至2020年美国国家健康与营养检查调查（NHANES）登记处的数据，进行了一项涉及9504名参与者的横断面研究，以评估血清铁状态与CRC风险之间的关系。该研究涵盖了来自美国各地、年龄在20至80岁之间、不同种族背景的男性和女性。参与者的特征用均值或比例表示。使用单变量和多变量分析来检查CRC的可能危险因素。采用逻辑回归模型，根据血清铁项目水平的每个分位数增量，估计CRC的比值比（OR）和95%置信区间（CI）。
结果
在进行全面调整后，我们的分析未发现血清铁、铁蛋白、转铁蛋白饱和度（TSAT）、总铁结合力（TIBC）与CRC风险之间存在统计学显著关联。虽然未观察到统计学显著差异，但与最低分位数相比，铁蛋白浓度升高似乎与CRC风险降低相关。具体而言，第二、第三和第四分位数（Q2、Q3和Q4）与最低分位数（Q1）相比的OR和95%CI如下：Q2（对比Q1），OR 0.403，95%CI 0.063 - 2.568；Q3（对比Q1），OR 0.316，95%CI 0.059 - 1.687；Q4（对比Q1），OR 0.250，95%CI 0.050 - 1.258。然而，这种趋势未达到统计学显著性（趋势P值 = 0.381）。
结论
我们的分析未证明血清铁状态与CRC风险之间存在统计学显著相关性。
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