Han Yuwen, Zhou Yuanshuai, Pan Jinlin, Sun Minxuan, Yang Jiao
School of Biomedical Engineering (Suzhou), Division of Life Sciences and Sciences and Medicine, University of Science and Technology of China, Hefei230026, China.
Jiangsu Key Lab of Medical Optics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Keling Road No.88, Suzhou215163, China.
Expert Rev Mol Med. 2024 Dec 4;27:e4. doi: 10.1017/erm.2024.34.
Glycosylation modifications of proteins and glycan hydrolysis are critical for protein function in biological processes. Aberrations in glycosylation enzymes are linked to lysosomal storage disorders (LSDs), immune interactions, congenital disorders and tumour progression. Mannosidase alpha class 2B member 1 (MAN2B1) is a lysosomal hydrolase from the α-mannosidase family. Dysfunction of MAN2B1 has been implicated as causative factors in mannosidosis, a lysosomal storage disorder characterised by cognitive impairment, hearing loss and immune system and skeletal anomalies. Despite decades of research, its role in pathogenic infections, autoimmune conditions, cancers and neurodegenerative pathologies is highly ambiguous. Future studies are required to shed more light on the intricate functioning of MAN2B1. To this end, we review the biological functions, expression patterns, enzymatic roles and potential implications of MAN2B1 across various cell types and disease contexts. Additionally, the novel insights presented in this review may aid in understanding the role of MAN2B1 in immune cells, thereby paving the way for targeted therapeutic interventions in immune-related disorders.
蛋白质的糖基化修饰和聚糖水解对于生物过程中的蛋白质功能至关重要。糖基化酶的异常与溶酶体贮积症、免疫相互作用、先天性疾病和肿瘤进展有关。甘露糖苷酶α 2B类成员1（MAN2B1）是一种来自α - 甘露糖苷酶家族的溶酶体水解酶。MAN2B1功能障碍被认为是甘露糖苷贮积症的致病因素之一，甘露糖苷贮积症是一种溶酶体贮积症，其特征为认知障碍、听力丧失以及免疫系统和骨骼异常。尽管经过了数十年的研究，但其在致病性感染、自身免疫性疾病、癌症和神经退行性疾病中的作用仍非常模糊。需要未来的研究来进一步阐明MAN2B1的复杂功能。为此，我们综述了MAN2B1在各种细胞类型和疾病背景下的生物学功能、表达模式、酶促作用及潜在影响。此外，本综述中提出的新见解可能有助于理解MAN2B1在免疫细胞中的作用，从而为免疫相关疾病的靶向治疗干预铺平道路。
