Romeni Simone, De Luca Daniela, Pierantoni Luca, Toni Laura, Marino Gabriele, Moccia Sara, Micera Silvestro
Modular Implantable Neurotechnologies Laboratory, Università Vita-Salute San Raffaele & Scuola Superiore Sant'Anna, Milan, Italy.
Bertarelli Foundation Chair in Translational Neural Engineering, Center for Neuroprosthetics and Institute of Bioengineering, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland.
iScience. 2024 Nov 5;27(12):111321. doi: 10.1016/j.isci.2024.111321. eCollection 2024 Dec 20.
Retinal stimulation (RS) allows restoring vision in blind patients, but it covers only a narrow region of the visual field. Optic nerve stimulation (ONS) has the potential to produce visual perceptions spanning the whole visual field, but it produces very irregular phosphenes. We introduced a geometrical model converting retinal and optic nerve firing rates into visual perceptions and vice versa and a method to estimate the best perceptions elicitable through an electrode configuration. We then compared in silico ONS and RS through simulated prosthetic vision of static and dynamic visual scenes. Both simulations and SPV experiments showed that it might be possible to reconstruct natural visual scenes with ONS and RS, and that ONS wide field-of-view allows the perception of more detail in dynamic scenarios than RS. Our findings suggest that ONS could represent an interesting approach for vision restoration and that our model can be used to optimize it.
视网膜刺激（RS）可使盲人恢复视力，但它仅覆盖视野的狭窄区域。视神经刺激（ONS）有可能产生覆盖整个视野的视觉感知，但会产生非常不规则的光幻视。我们引入了一个几何模型，可将视网膜和视神经的放电频率转换为视觉感知，反之亦然，还引入了一种方法来估计通过电极配置可引发的最佳感知。然后，我们通过模拟静态和动态视觉场景的假体视觉，在计算机模拟中比较了ONS和RS。模拟和假体视觉实验均表明，使用ONS和RS有可能重建自然视觉场景，并且ONS的宽视野在动态场景中比RS能感知到更多细节。我们的研究结果表明，ONS可能是一种有趣的视力恢复方法，并且我们的模型可用于对其进行优化。
