Zhou Jing, Xing Chen, Chen Yuting, Shen Jilu
Department of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Department of Clinical Laboratory, Anhui Public Health Clinical Center, Hefei, Anhui, China.
Front Public Health. 2024 Nov 19;12:1463190. doi: 10.3389/fpubh.2024.1463190. eCollection 2024.
Research increasingly links environmental exposure to toxic metals with health risks, yet the effect of combined metal exposure on infection remains underexplored. This study investigates the relationship between concurrent heavy metal exposure and infection in adults.
We analyzed data from 10,746 adults aged 20-80 from NHANES, with 1,869 positive for IgG. The study assessed associations between lead (Pb), cadmium (Cd), and mercury (Hg) with infection risk using single-metal logistic regression, RCS analysis, WQS regression, and qgcomp models.
Each metal showed an independent association with infection risk. Pb had a non-linear association, while Hg had a linear one. Analysis of multiple metals indicated a positive correlation between heavy metal exposure and infection risk, particularly in younger and middle-aged adults, with Pb showing the strongest link.
Our findings reveal a significant association between heavy metal exposure and infection risk, especially in younger demographics, with lead being a key factor. This highlights the importance of understanding environmental metal exposure's impact on public health and informs the development of prevention strategies.
研究越来越多地将环境中有毒金属暴露与健康风险联系起来，但金属联合暴露对感染的影响仍未得到充分探索。本研究调查了成年人同时暴露于重金属与感染之间的关系。
我们分析了来自美国国家健康与营养检查调查（NHANES）的10746名年龄在20至80岁之间成年人的数据，其中1869人IgG呈阳性。该研究使用单金属逻辑回归、限制性立方样条（RCS）分析、加权分位数和（WQS）回归以及qgcomp模型评估铅（Pb）、镉（Cd）和汞（Hg）与感染风险之间的关联。
每种金属都与感染风险存在独立关联。铅呈现非线性关联，而汞呈现线性关联。多种金属分析表明重金属暴露与感染风险之间存在正相关，尤其是在年轻人和中年人中，铅的关联最为显著。
我们的研究结果揭示了重金属暴露与感染风险之间存在显著关联，尤其是在年轻人群中，铅是一个关键因素。这凸显了了解环境金属暴露对公众健康影响的重要性，并为预防策略的制定提供了依据。
