对……进行代谢工程改造以增强有价值天然产物的合成。 （原句中“of”后面缺少具体内容）
Metabolic engineering of to enhance the synthesis of valuable natural products.
作者信息
Xu Zuwei, Ji Lihao, Tang Wenxiu, Guo Liang, Gao Cong, Chen Xiulai, Liu Jia, Hu Guipeng, Liu Liming
机构信息
State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
School of Life Sciences and Health Engineering, Jiangnan University, Wuxi 214122, China.
出版信息
Eng Microbiol. 2022 Apr 23;2(2):100022. doi: 10.1016/j.engmic.2022.100022. eCollection 2022 Jun.
The mycelial bacterium is a workhorse for producing natural products, serving as a key source of drugs and other valuable chemicals. However, its complicated life cycle, silent biosynthetic gene clusters (BGCs), and poorly characterized metabolic mechanisms limit efficient production of natural products. Therefore, a metabolic engineering strategy, including traditional and emerging tools from different disciplines, was developed to further enhance natural product synthesis by . Here, current trends in systems metabolic engineering, including tools and strategies, are reviewed. Particularly, this review focuses on recent developments in the selection of methods for regulating the life cycle, strategies for the activation of silent gene clusters, and the exploration of regulatory mechanisms governing antibiotic production. Finally, future challenges and prospects are discussed.
丝状真菌是生产天然产物的主力军，是药物和其他有价值化学品的关键来源。然而，其复杂的生命周期、沉默的生物合成基因簇（BGCs）以及表征不佳的代谢机制限制了天然产物的高效生产。因此，开发了一种代谢工程策略，包括来自不同学科的传统和新兴工具，以进一步提高丝状真菌的天然产物合成。在此，综述了系统代谢工程的当前趋势，包括工具和策略。特别是，本综述重点关注调节丝状真菌生命周期方法的选择、沉默基因簇激活策略以及抗生素生产调控机制探索的最新进展。最后，讨论了未来的挑战和前景。
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