Patel Salina, Naik Lincoln, Rai Ankita, Palit Krishna, Kumar Ashish, Das Mousumi, Nayak Dev Kiran, Dandsena Pramathesh Kumar, Mishra Amit, Singh Ramandeep, Dhiman Rohan, Das Surajit
Laboratory of Mycobacterial Immunology, Department of Life Science, National Institute of Technology, Rourkela, 769 008, Odisha, India.
Laboratory of Environmental Microbiology and Ecology, Department of Life Science, National Institute of Technology, Rourkela, 769 008, Odisha, India.
Arch Microbiol. 2025 Feb 17;207(3):64. doi: 10.1007/s00203-024-04233-8.
The bacterial genus Streptomyces is known for the prolific production of secondary metabolites, which exhibit remarkable structural diversity and potent biological activities. Tuberculosis (TB) remains a formidable global health challenge exacerbated by the emergence of antimicrobial resistance (AMR), necessitating the discovery of novel therapeutic agents. The untapped potential of marine Streptomyces-derived secondary metabolites offers a promising avenue for screening anti-tubercular (anti-TB) compounds with unique chemical structures and potential bioactive properties. The review emphasizes the diverse marine habitats and Streptomyces with novel anti-TB bioactive metabolites. It discusses fermentation and bioprocessing strategies for screening anti-TB drugs. This review also covers the chemical diversity, potency, mechanism of action, and structures of about seventy anti-TB compounds discovered from marine Streptomyces. These compounds span various chemical classes, including quinones, macrolactams, macrolides, phenols, esters, anthracyclines, peptides, glycosides, alkaloids, piperidones, thiolopyrrolones, nucleosides, terpenes, flavonoids, polyketides, and actinomycins. It emphasizes the need to explore marine ecosystems to discover more novel anti-TB natural products.
链霉菌属细菌以大量生产次级代谢产物而闻名，这些次级代谢产物具有显著的结构多样性和强大的生物活性。结核病（TB）仍然是一项严峻的全球健康挑战，抗菌药物耐药性（AMR）的出现使其进一步恶化，因此需要发现新型治疗药物。海洋来源的链霉菌次级代谢产物尚未开发的潜力为筛选具有独特化学结构和潜在生物活性的抗结核（抗TB）化合物提供了一条有前景的途径。这篇综述强调了具有新型抗结核生物活性代谢产物的多样海洋栖息地和链霉菌。它讨论了筛选抗结核药物的发酵和生物加工策略。这篇综述还涵盖了从海洋链霉菌中发现的约70种抗结核化合物的化学多样性、效力、作用机制和结构。这些化合物涵盖各种化学类别，包括醌类、大环内酰胺类、大环内酯类、酚类、酯类、蒽环类、肽类、糖苷类、生物碱类、哌啶酮类、硫代吡咯酮类、核苷类、萜类、黄酮类、聚酮类和放线菌素类。它强调了探索海洋生态系统以发现更多新型抗结核天然产物的必要性。
