Mueller Jonathan Wolf, Fietz Daniela, Dias Irundika H K
Metabolism and Systems Science, College of Medicine and Health, University of Birmingham, Birmingham, U.K.
Institute for Veterinary Anatomy, Histology and Embryology, Justus Liebig University, Giessen, Germany.
Essays Biochem. 2024 Dec 4;68(4):379-382. doi: 10.1042/EBC20230099.
Sulfation pathways are an essential part of overall sulfur metabolism. Sulfation pathways are mainly about sulfate activation, and the making and breaking of biological sulfate esters. This special issue features some extended reflection on what was presented at the SUPA 2023 meeting on Sulfation Pathways. Novel insights into the synthesis and analytics of sulfate, of sulfated conjugates, and of protein persulfides are presented. Oxysterol sulfates are presented as emerging sulfo-metabolites. Sulfation pathways enzymes are discussed in various disease settings. This special issue also presents insights into polysaccharide sulfotransferases and their functional characterization. Finally, cytoplasmic sulfotransferases are highlighted with regards to their impact on DNA-modification, and in the context of endocrine disruptors. All in all, thought-provoking findings, with the potential to guide and stimulate future research in the field of sulfation pathways and beyond.
硫酸化途径是整体硫代谢的重要组成部分。硫酸化途径主要涉及硫酸盐激活以及生物硫酸酯的生成与分解。本期特刊对在2023年硫酸化途径SUPA会议上所展示的内容进行了一些深入思考。文中介绍了关于硫酸盐、硫酸化共轭物和蛋白质过硫化物的合成与分析的新见解。氧化甾醇硫酸盐作为新兴的硫代谢产物被呈现。在各种疾病背景下对硫酸化途径酶进行了讨论。本期特刊还介绍了对多糖硫酸转移酶及其功能特性的见解。最后，强调了细胞质硫酸转移酶对DNA修饰的影响以及在内分泌干扰物背景下的作用。总而言之，这些发人深省的研究结果有可能指导和推动硫酸化途径及其他领域的未来研究。
