Li Mengya, Jin Jianjing, Zhai Xiaohui, Zhu Ting, Zhao Xixia, Wang Dongshi
Faculty of Sports Science, Ningbo University, Zhejiang, PR China.
Mental Health and Guidance Center, Ningbo University, Zhejiang, PR China.
Physiol Behav. 2025 Mar 1;290:114775. doi: 10.1016/j.physbeh.2024.114775. Epub 2024 Dec 2.
Chronic methamphetamine use is frequently associated with impairments in the attentional network (alerting, orienting, conflict networks) and related brain regions, which significantly trigger METH-related cravings. The aim of this study is to investigate the effects of moderate-intensity acute aerobic exercise on cravings and attentional networks in individuals with methamphetamine use disorders (MUD).
Using a cross-over design, this study recruited 32 male MUDs to randomly complete a 30min moderate-intensity aerobics exercise condition (65%-75% HRmax) and an assigned material reading control condition, with a 7-day washout interval. All participants completed Visual Analog Scales before, during, and after exercise, until the HR dropped to 110% of the resting heart rate, in preparation for the Attention Network Test (ANT).
The aerobic exercise significantly reduces the participants' cravings. There were no differences observed in the efficiency of alerting and orienting networks between the aerobic exercise and control conditions, however, the efficiency of conflict network was enhanced after exercise. Furthermore, the results showed a significant negative correlation between the enhancements in conflict network efficiency and the reductions in post-exercise craving scores for both conditions.
Moderate-intensity acute aerobic exercise significantly improves the attentional network, especially enhancing the conflict network in individuals with MUD. Additionally, the improvement of the conflict network is closely related to the reduction in cravings in individuals with MUD, suggesting that aerobic exercise may reduce cravings through improvements in cognitive function.
长期使用甲基苯丙胺常与注意力网络（警觉、定向、冲突网络）及相关脑区功能受损有关，这会显著引发与甲基苯丙胺相关的渴望。本研究旨在探讨中等强度急性有氧运动对甲基苯丙胺使用障碍（MUD）个体的渴望及注意力网络的影响。
本研究采用交叉设计，招募了32名男性MUD患者，随机让他们完成30分钟中等强度有氧运动（心率最大值的65%-75%）和指定的材料阅读对照条件，洗脱期为7天。所有参与者在运动前、运动期间和运动后完成视觉模拟量表，直到心率降至静息心率的110%，为注意力网络测试（ANT）做准备。
有氧运动显著降低了参与者的渴望。有氧运动和对照条件之间在警觉和定向网络效率方面未观察到差异，然而，运动后冲突网络的效率有所提高。此外，结果显示，在两种条件下，冲突网络效率的提高与运动后渴望得分的降低之间存在显著负相关。
中等强度急性有氧运动显著改善注意力网络，特别是增强了MUD个体的冲突网络。此外，冲突网络的改善与MUD个体渴望的减少密切相关，这表明有氧运动可能通过改善认知功能来减少渴望。
