Huang Yiqi, Zhou Jiazhen, Deng Yaotang, Li Guoliang, He Shuirong, Li Hecheng, Liu Lili
Institute of Toxicology, Guangdong Provincial Hospital for Occupational Disease Prevention and Treatment, Guangzhou 510310, China; School of Public Health, Guangzhou Medical University, Guangzhou 511436, China.
Institute of Toxicology, Guangdong Provincial Hospital for Occupational Disease Prevention and Treatment, Guangzhou 510310, China.
Clin Chim Acta. 2025 Feb 1;567:120049. doi: 10.1016/j.cca.2024.120049. Epub 2024 Dec 2.
MicroRNAs (miRNAs), a class of endogenous small RNAs with lengths of approximately 19-24 nucleotides, play important regulatory roles in cells. In recent years, miR-363 has emerged as a prominent member of the miR-92a family, participating in various biological functions, including cellular proliferation, cycle, migration, and apoptosis. In particular, miR-363 plays a critical role in acute kidney injury, renal fibrosis, and diabetic nephropathy and can serve as a biomarker for the diagnosis of renal cell carcinoma. Ongoing research is exploring its potential as a biomarker of other kidney diseases. This review focuses on the role of miR-363 in kidney diseases, elucidating its regulatory mechanisms and exploring its possible value as a biomarker of kidney diseases.
微小RNA（miRNA）是一类长度约为19 - 24个核苷酸的内源性小RNA，在细胞中发挥重要的调节作用。近年来，miR - 363已成为miR - 92a家族的重要成员，参与多种生物学功能，包括细胞增殖、周期、迁移和凋亡。特别是，miR - 363在急性肾损伤、肾纤维化和糖尿病肾病中起关键作用，可作为肾细胞癌诊断的生物标志物。正在进行的研究正在探索其作为其他肾脏疾病生物标志物的潜力。本综述重点关注miR - 363在肾脏疾病中的作用，阐明其调节机制，并探索其作为肾脏疾病生物标志物的可能价值。
