微小 RNA 在肾脏疾病中的调控作用与功能。
The regulation and function of microRNAs in kidney diseases.
机构信息
Department of Cellular Biology and Anatomy, Medical College of Georgia, Georgia Regents University and Charlie Norwood Veterans Affairs Medical Center, Augusta, GA 30912, USA.
出版信息
IUBMB Life. 2013 Jul;65(7):602-14. doi: 10.1002/iub.1174.
Abstract
MicroRNAs (miRNA) are endogenous short noncoding RNAs, which regulate virtually all major cellular processes by inhibiting target gene expression. In kidneys, miRNAs have been implicated in renal development, homeostasis, and physiological functions. In addition, miRNAs play important roles in the pathogenesis of various renal diseases, including renal carcinoma, diabetic nephropathy, acute kidney injury, hypertensive nephropathy, polycystic kidney disease, and others. Furthermore, miRNAs may have great values as biomarkers in different kidney diseases.
摘要
微小 RNA（miRNA）是内源性的短非编码 RNA，通过抑制靶基因表达来调节几乎所有主要的细胞过程。在肾脏中，miRNA 参与肾脏发育、稳态和生理功能。此外，miRNA 在各种肾脏疾病的发病机制中发挥重要作用，包括肾细胞癌、糖尿病肾病、急性肾损伤、高血压肾病、多囊肾病等。此外，miRNA 作为不同肾脏疾病的生物标志物可能具有很大的价值。
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