Tokuno Hisaki, Tanaka Miyuu, Izawa Takeshi, Sasai Hiroshi, Kuwamura Mitsuru
Laboratory of Veterinary Pathology, Graduate School of Veterinary Sciences, Osaka Metropolitan University, Osaka, Japan.
Kitasuma Animal Hospital, Hyogo, Japan.
J Vet Med Sci. 2025 Jan 10;87(1):86-89. doi: 10.1292/jvms.24-0438. Epub 2024 Dec 3.
A 6-year-old male rabbit (Oryctolagus cuniculus) showed loss of appetite, right side rotating and the left side circling. The symptoms did not improve, and the rabbit died on the 2nd day after presentation. Histological evaluation of the brain revealed a non-demarcated high cellularity area of neoplastic cells in the midbrain. In the lesion, neoplastic proliferation of large pleomorphic cells with irregular nuclei and medium amount of cytoplasm with prominent atypia was observed. Most of the neoplastic cells were immunohistochemically positive for both Olig2 and vimentin, and filamentous structure was seen in the cytoplasm. To our knowledge, this is the first report of anaplastic oligodendroglioma in a pet rabbit.
一只6岁雄性家兔（穴兔）出现食欲不振、向右侧旋转和左侧转圈的症状。症状未改善，该家兔在就诊后第2天死亡。对脑部进行组织学评估发现中脑有一个边界不清的肿瘤细胞高细胞区。在病变中，观察到具有不规则核和中等量细胞质且有明显异型性的大的多形性细胞的肿瘤性增殖。大多数肿瘤细胞免疫组化检测Olig2和波形蛋白均呈阳性，且在细胞质中可见丝状结构。据我们所知，这是宠物兔间变性少突胶质细胞瘤的首例报告。
