Naramoto Kanami, Kitahara Go, Nazhat Sayed Ahmad, Yasuda Masahiro, Osawa Takeshi
Laboratory of Theriogenology, Department of Veterinary Sciences, Faculty of Agriculture, University of Miyazaki, Miyazaki, Japan.
Clinic Department, Faculty of Veterinary Science, Kabul University, Kabul, Afghanistan.
J Vet Med Sci. 2025 Jan 10;87(1):97-102. doi: 10.1292/jvms.24-0177. Epub 2024 Dec 3.
To clarify the profile of endometrial cytokines and their relation to inflammation and fertility, mRNA expressions of interleukin (IL)-1α, -1β, -8, -10 and tumor necrosis factor (TNF)-α at weeks (W) 3, 5, and 7 postpartum were compared between Holstein cows without and with cytological endometritis and between early (≤90 days) and delayed (>90 days postpartum) conception cows. IL-1α, IL-1β, and IL-8 expressions at W5 and W7 were significantly higher in cows with cytological endometritis than without. While IL-1α, IL-1β, IL-8, and TNF-α expressions decreased from W3 to W5 in all early conception cows, the percentage of cows decreasing these mRNA was significantly lower in delayed conception cows than early conception cows. Evaluating endometrial cytokine expression in dairy cows helps diagnose cytological endometritis and estimate fertility.
为了阐明子宫内膜细胞因子的概况及其与炎症和生育力的关系，比较了产后第3周、第5周和第7周时，无细胞学子宫内膜炎和有细胞学子宫内膜炎的荷斯坦奶牛之间，以及早期（≤90天）和延迟（>90天产后）受孕奶牛之间白细胞介素（IL）-1α、-1β、-8、-10和肿瘤坏死因子（TNF）-α的mRNA表达。有细胞学子宫内膜炎的奶牛在第5周和第7周时IL-1α、IL-1β和IL-8的表达显著高于无细胞学子宫内膜炎的奶牛。在所有早期受孕奶牛中，IL-1α、IL-1β、IL-8和TNF-α的表达从第3周降至第5周，而在延迟受孕奶牛中，这些mRNA表达下降的奶牛百分比显著低于早期受孕奶牛。评估奶牛子宫内膜细胞因子表达有助于诊断细胞学子宫内膜炎并估计生育力。
