Varin Christophe, de Kerchove d'Exaerde Alban
Université Libre de Bruxelles (ULB), ULB Neuroscience Institute, Neurophysiology Laboratory, Brussels, Belgium.
Trends Neurosci. 2025 Jan;48(1):77-91. doi: 10.1016/j.tins.2024.11.003. Epub 2024 Dec 3.
The dorsal striatum is instrumental in regulating motor control and goal-directed behaviors. The classical description of the two output pathways of the dorsal striatum highlights their antagonistic control over actions. However, recent experimental evidence implicates both pathways and their coordinated activities during actions. In this review, we examine the different models proposed for striatal encoding of actions during self-paced behaviors and how they can account for evidence harvested during goal-directed behaviors. We also discuss how the activation of striatal ensembles can be reshaped and reorganized to support the formation of instrumental learning and behavioral flexibility. Future work integrating these considerations may resolve controversies regarding the control of actions by striatal networks.
背侧纹状体在调节运动控制和目标导向行为中起重要作用。对背侧纹状体两条输出通路的经典描述强调了它们对动作的拮抗控制。然而，最近的实验证据表明，在动作过程中这两条通路及其协同活动都有涉及。在这篇综述中，我们研究了为自定节奏行为期间纹状体对动作的编码所提出的不同模型，以及它们如何解释在目标导向行为中获得的证据。我们还讨论了纹状体神经元群的激活如何能够被重塑和重组，以支持工具性学习的形成和行为灵活性。整合这些考虑因素的未来工作可能会解决关于纹状体网络对动作控制的争议。
