Rodriguez Elena Chaves, Naudé Jérémie, Rial Daniel, de Kerchove d'Exaerde Alban
Neurophy Laboratory, ULB Neuroscience Institute, Université Libre de Bruxelles (ULB), 808 route de Lennik, 1070 Brussels, Belgium.
Institut de Génomique Fonctionnelle, Univ. Montpellier - UMR 5203 CNRS - U 1191 INSERM, Montpellier, France.
Sci Adv. 2025 May 30;11(22):eadq0484. doi: 10.1126/sciadv.adq0484. Epub 2025 May 28.
The striatum plays a key role in decision-making, with its effects varying with anatomical location and direct and indirect pathway striatal projecting neuron (d- and iSPN) populations. Using a mouse gambling task with a reinforcement-learning model, we described individual decision-making profiles as a combination of three archetypal strategies: Optimizers, Risk-averse, and Explorers. These strategies reflected stable differences in the parameters generating decisions (sensitivity to the reward magnitude, to risk, or to punishment) derived from a reinforcement-learning model of animal choice. Chemogenetic manipulation showed that dorsomedial striatum (DMS) neurons substantially affect decision-making, while the nucleus accumbens (NAc) and dorsolateral striatum neurons (DLS) have lesser or no effects, respectively. Specifically, DMS dSPNs decrease risk aversion by increasing the perceived value of risky choices, while DMS iSPNs emphasize large gains, affecting decisions depending on decision-making profiles. Hence, we propose that striatal populations from different subregions influence distinct decision-making parameters, leading to profile-dependent choices.
纹状体在决策过程中起着关键作用，其作用因解剖位置以及直接和间接通路纹状体投射神经元（d-和iSPN）群体的不同而有所差异。通过使用带有强化学习模型的小鼠赌博任务，我们将个体决策概况描述为三种原型策略的组合：优化者、风险规避者和探索者。这些策略反映了从动物选择的强化学习模型中得出的决策生成参数（对奖励大小、风险或惩罚的敏感性）的稳定差异。化学遗传学操作表明，背内侧纹状体（DMS）神经元对决策有实质性影响，而伏隔核（NAc）和背外侧纹状体神经元（DLS）分别影响较小或无影响。具体而言，DMS dSPNs通过增加对风险选择的感知价值来降低风险规避，而DMS iSPNs强调大幅收益，根据决策概况影响决策。因此，我们提出来自不同亚区域的纹状体群体影响不同的决策参数，从而导致依赖于概况的选择。
