卡马西平引起的血浆氟哌啶醇水平降低会使精神症状恶化吗？
Does carbamazepine-induced reduction of plasma haloperidol levels worsen psychotic symptoms?
作者信息
Arana G W, Goff D C, Friedman H, Ornsteen M, Greenblatt D J, Black B, Shader R I
出版信息
Am J Psychiatry. 1986 May;143(5):650-1. doi: 10.1176/ajp.143.5.650.
PMID:3963258
Abstract
Seven psychotic patients' plasma haloperidol levels, determined with gas-liquid chromatography, fell a mean of 60% when carbamazepine treatment was instituted. Two patients' levels became undetectable, and their symptoms worsened. Haloperidol level monitoring may be required for patients given both haloperidol and carbamazepine.
摘要
通过气液色谱法测定的7名精神病患者的血浆氟哌啶醇水平，在开始使用卡马西平治疗后平均下降了60%。两名患者的水平变得无法检测到，且他们的症状恶化。同时服用氟哌啶醇和卡马西平的患者可能需要监测氟哌啶醇水平。
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