通过可见光诱导聚合在单个活细胞上形成生物相容性水凝胶涂层。
Biocompatible hydrogel coating on single living cells through visible light-induced polymerization.
作者信息
Jung Young Jae, Choi Hyunwoo, Choi Insung S, Lee Jungkyu K
机构信息
Department of Chemistry and Green-Nano Materials Research Center, Kyungpook National University, Daegu 41566, South Korea.
Department of Chemistry, KAIST, Daejeon 34141, South Korea.
出版信息
Chem Commun (Camb). 2024 Dec 19;61(2):322-325. doi: 10.1039/d4cc03075c.
Visible light-mediated photocatalysis leads to the efficient hydrogel coating of individual mammalian cells, functionalized with biocompatible anchor molecules tagged with fluorescein serving as a trifecta: photocatalyst, initiator, and fluorophore. NIH3T3 fibroblast cells are encapsulated within hydrogel shells of poly(ethylene glycol) diacrylate (PEGDA) and -vinylpyrrolidone without any noticeable decrease in cell viability.
可见光介导的光催化作用可实现对单个哺乳动物细胞的高效水凝胶包被，这些细胞用标记有荧光素的生物相容性锚定分子进行功能化，荧光素起到了三重作用：光催化剂、引发剂和荧光团。NIH3T3成纤维细胞被包裹在聚（乙二醇）二丙烯酸酯（PEGDA）和乙烯基吡咯烷酮的水凝胶壳中，细胞活力没有任何明显下降。
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