Kaur Navjot, Sahoo Jagabandhu, De Mrinmoy
Department of Organic Chemistry, Indian Institute of Science, Bangalore, 560012, India.
Chembiochem. 2025 Jan 2;26(1):e202400693. doi: 10.1002/cbic.202400693. Epub 2024 Dec 5.
Bacterial infections continue to threaten public health due to limitations in rapid and accurate diagnostic techniques. While broad-spectrum antibiotics offer empirical treatment, their overuse has fuelled the emergence of antimicrobial resistance (AMR) pathogens, posing a critical global public health challenge. In this critical scenario, nanomaterial-based antibacterial agents emerge as a promising solution to combat bacteria and inhibit their proliferation. However, selective elimination of pathogenic bacteria is paramount. This review highlights recent advancements in developing nanomaterials for selective antibacterial activity. We categorize these agents based on their mode of action, exploring how they selectively interact with bacteria and their potential antibacterial mechanisms. This review offers crucial insights for researchers exploring the potential of nanotechnology to address the growing threat of AMR.
由于快速准确诊断技术的局限性，细菌感染持续威胁着公众健康。虽然广谱抗生素提供了经验性治疗，但它们的过度使用助长了抗菌药物耐药性（AMR）病原体的出现，构成了一项严峻的全球公共卫生挑战。在这一关键情形下，基于纳米材料的抗菌剂成为对抗细菌并抑制其增殖的一种有前景的解决方案。然而，选择性清除病原菌至关重要。本综述着重介绍了开发具有选择性抗菌活性的纳米材料的最新进展。我们根据其作用方式对这些制剂进行分类，探讨它们如何与细菌选择性相互作用及其潜在的抗菌机制。本综述为探索纳米技术应对AMR日益增长威胁潜力的研究人员提供了关键见解。
