Han Xuesong, Ogongo Margaret Katana, Tian Feng, Zhao Jingxuan, Zheng Zhiyuan, Liu Zuyun, Yabroff K Robin
Surveillance and Health Equity Science, American Cancer Society, 270 Peachtree Street NW, Suite 1300, Atlanta, GA, 30303, USA.
MD Anderson Cancer Center, Huston, TX, USA.
Cancer Causes Control. 2025 Apr;36(4):379-388. doi: 10.1007/s10552-024-01941-w. Epub 2024 Dec 4.
Cancer and its treatments may accelerate the aging process. However, accelerated aging among cancer survivors is not well understood. This study examines accelerated aging among adults with and without a cancer history in a nationally representative sample and identifies health-related social needs and behavioral factors associated with accelerated aging.
We conducted a cross-sectional study of 11,432 adults aged 20-84 years from the 1999 to 2010 National Health and Nutrition Examination Survey, including 728 cancer survivors. Accelerated aging was measured by validated Phenotypic Age Acceleration (PhenoAgeAccel) based on clinical chemistry biomarkers. We described accelerated aging by cancer history, demographics, health-related social needs, and health behaviors, and utilized weighted linear regression to assess their associations with accelerated aging.
Majority of the sample were < 65 years old (n = 8,800, weighted percentage = 84.8%), female (n = 5,856, 50.8%), and non-Hispanic White (n = 5,709, 71.7%). Cancer survivors experienced an average of 0.14 (95% CI 0.03, 0.24) years of accelerated aging measured by PhenoAgeAccel. Individuals who were male, unmarried, less educated, with lower-income, or with 3 or more medical conditions also had accelerated aging regardless of cancer history. Moreover, health-related social needs in food insecurity, unemployment, health insurance and coverage continuity as well as obesity and smoking were associated with accelerated aging in both cancer survivors and individuals without a cancer history.
Cancer survivors experience accelerated aging in the US. Addressing health-related social needs and promoting healthy behaviors in care delivery may advance healthy aging.
癌症及其治疗可能会加速衰老过程。然而，癌症幸存者中的加速衰老现象尚未得到充分了解。本研究在一个具有全国代表性的样本中，调查有和没有癌症病史的成年人中的加速衰老情况，并确定与加速衰老相关的健康相关社会需求和行为因素。
我们对1999年至2010年全国健康与营养检查调查中11432名年龄在20 - 84岁的成年人进行了横断面研究，其中包括728名癌症幸存者。基于临床化学生物标志物，通过经过验证的表型年龄加速（PhenoAgeAccel）来测量加速衰老。我们按癌症病史、人口统计学特征、健康相关社会需求和健康行为描述了加速衰老情况，并利用加权线性回归评估它们与加速衰老的关联。
样本中的大多数人年龄小于65岁（n = 8800，加权百分比 = 84.8%），女性（n = 5856，50.8%），非西班牙裔白人（n = 5709，71.7%）。通过PhenoAgeAccel测量，癌症幸存者平均经历了0.14（95%可信区间0.03，0.24）年的加速衰老。无论有无癌症病史，男性、未婚、受教育程度较低、收入较低或患有3种或更多疾病的个体也存在加速衰老。此外，食品不安全、失业、健康保险和保险覆盖连续性等健康相关社会需求以及肥胖和吸烟与癌症幸存者和无癌症病史个体的加速衰老均有关联。
在美国，癌症幸存者经历加速衰老。在医疗服务中满足健康相关社会需求并促进健康行为可能有助于推动健康老龄化。
