Ying Shuo, Chen Qiang, Tang Jichao, Cai Han, Zhang Li, Zhang Jing, Fu Naikuan, Zhang Peng
Tianjin Chest Hospital, Tianjin, China.
Tianjin University, Tianjin, China.
BMC Cardiovasc Disord. 2024 Dec 4;24(1):701. doi: 10.1186/s12872-024-04379-9.
Spontaneous coronary artery dissection (SCAD) is a significant cause of non-atherosclerotic acute coronary syndrome, myocardial infarction, and sudden cardiac death. Women account for 87-95% of SCAD patients, with the average age of onset ranging from 44 to 53 years. Approximately 95% of cases reported to resolve spontaneously. However, percutaneous coronary intervention (PCI) can lead to various complications, prompting guidelines to recommend conservative management for patients categorized as low-risk.
A 49-year-old woman presented with intermittent dyspnea lasting three months. Initial coronary angiography revealed severe stenosis of the left anterior descending artery (LAD). Intravascular ultrasound (IVUS) demonstrated dissection, hematoma, and thrombus in the proximal LAD. Following balloon dilation, the hematoma extended distally, resulting in no-reflow, which subsequently led to thrombosis in the left main coronary artery. A stent was deployed from the mid to proximal LAD, leading to gradual improvement in blood flow, achieving TIMI grade 3. Two months post-discharge, the patient was readmitted. Coronary angiography showed patent stents, with no significant stenosis in the previously placed stent, but a new stent was inserted in the distal segment of the LAD. Eight months later, repeat angiography revealed patent stents and no notable abnormalities in the remaining vessels.
For high-risk SCAD patients who do not exhibit spontaneous healing, vascular revascularization should be considered judiciously.
Not applicable.
自发性冠状动脉夹层(SCAD)是非动脉粥样硬化性急性冠状动脉综合征、心肌梗死和心源性猝死的重要原因。女性占SCAD患者的87 - 95%,平均发病年龄在44至53岁之间。据报道,约95%的病例可自发缓解。然而,经皮冠状动脉介入治疗(PCI)可能导致各种并发症,促使指南建议对低风险患者进行保守治疗。
一名49岁女性出现间歇性呼吸困难,持续3个月。初次冠状动脉造影显示左前降支(LAD)严重狭窄。血管内超声(IVUS)显示LAD近端有夹层、血肿和血栓。球囊扩张后,血肿向远端扩展,导致无复流,随后左主干冠状动脉发生血栓形成。在LAD中至近端置入一枚支架,血流逐渐改善,达到TIMI 3级。出院后2个月,患者再次入院。冠状动脉造影显示支架通畅,先前置入的支架无明显狭窄,但在LAD远端节段插入了一枚新支架。8个月后,重复造影显示支架通畅,其余血管无明显异常。
对于未表现出自发性愈合的高危SCAD患者,应谨慎考虑血管重建术。
不适用。