Spiegel H U, Bergermann M, Hauss J, Wendt M, Schönleben K
Anaesthesist. 1986 Jan;35(1):36-42.
On the basis of investigations of three groups of dogs (7 in each) the effects of high dosage piritramide anesthesia were analyzed. Using a standardized technique no significant changes in hemodynamics and microcirculation were found during 4 h. So variations in the "steady-state" must be attributed to additional medication or therapeutic intervention. High dosage piritramide anesthesia has been applied in more than 250 animal experiments.
在对三组犬（每组7只）进行研究的基础上，分析了高剂量匹利卡明麻醉的效果。采用标准化技术，在4小时内未发现血流动力学和微循环有显著变化。因此，“稳态”的变化必须归因于额外的药物治疗或治疗干预。高剂量匹利卡明麻醉已应用于250多项动物实验中。
