Seitz W, Lübbe N, Kirchner E
Anaesthesist. 1986 Feb;35(2):108-10.
The respiratory depressant effects of 0.25 mg/kg nalbuphine were analyzed in detail in seven healthy volunteers by determining the CO2 response (Read's method) and the mouth occlusion pressure (Whitelaw's method) before and 10, 30 and 60 min after administration of the drug. Minute ventilation VE (PACO2 = 55 mm Hg) decreased after nalbuphine by a maximum of 36.4% (P less than 0.05). Simultaneously, the slope of the right-shifted CO2 response curve was diminished by 21.1% (NS) while the mouth occlusion pressure decreased by 36.3% (P less than 0.05), respectively. There were only slight changes in mean inspiratory flow rate. These findings demonstrate that nalbuphine does not lead to relevant impairment of central respiratory regulation or respiratory mechanics.
通过在7名健康志愿者中，于给药前以及给药后10、30和60分钟测定二氧化碳反应（里德法）和口腔阻断压（惠特劳法），详细分析了0.25毫克/千克纳布啡的呼吸抑制作用。纳布啡给药后，分钟通气量VE（肺泡二氧化碳分压=55毫米汞柱）最大降低了36.4%（P<0.05）。同时，右移的二氧化碳反应曲线斜率分别减小了21.1%（无统计学意义），而口腔阻断压降低了36.3%（P<0.05）。平均吸气流量仅有轻微变化。这些发现表明，纳布啡不会导致中枢呼吸调节或呼吸力学的相关损害。
