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绘制2型糖尿病中的线粒体图谱:2003年至2023年的关键发现。

Mapping the mitochondrial landscape in T2DM: key findings from 2003-2023.

作者信息

Tan Yi, Liu Mingjun, Zhou Xinfeng, Gao Tianjiao, Fang Jinxu, Wang Sixian, Chen Shaotao

机构信息

Departments of Acupuncture and Massage, Changchun University of Chinese Medicine, Changchun, Jilin, China.

The Affliated Hospital of Changchun University of Chinese Medicine, Changchun, Jilin, China.

出版信息

Front Endocrinol (Lausanne). 2024 Nov 20;15:1474232. doi: 10.3389/fendo.2024.1474232. eCollection 2024.

DOI:10.3389/fendo.2024.1474232
PMID:39634184
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11614640/
Abstract

BACKGOUND

T2DM, a chronic metabolic disorder, poses a significant threat to global public health. Mitochondria play a crucial role in the pathogenesis of T2DM. This study intends to investigate the correlation between mitochondria and T2DM over the past two decades (2003-2023) through bibliometric analysis. Its objectives are to pinpoint trends, emphasize research priorities, and establish a foundation for future investigations.

METHODS

A literature search was conducted using the SCI-E database. All recorded results were downloaded in plain text format for further analysis. The following terms were analyzed using Vosviewer 1.6.18, citespace 6.3r1, bibliometrix in RStudio (v.4.4.1), and Microsoft Excel 2021: country, institution, author, journal, references, and keywords.

RESULTS

From January 1, 2003 to December 31, 2023, a total of 2,732 articles were retrieved. The United States, China, and Italy contributed most of the records. UNIVERSITY OF CALIFORNIA SYSTEM, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICAL INSERM, and US DEPARTMENT OF VETERANS AFFAIRS were the top 3 most productive institutions. rocha milagros, victor victor m had the most publications, followed by roden michael, and petersen kf had the most citations together. DIABETES published the most articles on research on this topic, followed by AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, DIABETOLOGIA. The key points of this topic are the relationship between mitochondria and T2DM, the skeletal muscle mitochondrial changes observed in T2DM, and the impact of mitochondrial dysfunction on T2DM. Over the past five years, particle dynamics, mitochondrial dysfunction, and mechanism research have emerged as significant focal points in this field.

CONCLUDE

This paper successfully identified the key areas and emerging trends in the relationship between mitochondria and T2DM, thereby offering valuable insights for future research.

摘要

背景

2型糖尿病是一种慢性代谢性疾病,对全球公共卫生构成重大威胁。线粒体在2型糖尿病的发病机制中起着至关重要的作用。本研究旨在通过文献计量分析,调查过去二十年(2003 - 2023年)线粒体与2型糖尿病之间的相关性。其目的是确定趋势、强调研究重点,并为未来的研究奠定基础。

方法

使用SCI - E数据库进行文献检索。所有记录结果均以纯文本格式下载以便进一步分析。使用Vosviewer 1.6.18、CiteSpace 6.3r1、RStudio(v.4.4.1)中的bibliometrix以及Microsoft Excel 2021对以下内容进行分析:国家、机构、作者、期刊、参考文献和关键词。

结果

2003年1月1日至2023年12月31日,共检索到2732篇文章。美国、中国和意大利贡献了大部分记录。加利福尼亚大学系统、法国国家健康与医学研究院、美国退伍军人事务部是发文量最多的前3个机构。罗查·米拉格罗斯、维克托·维克托·M发表的文章最多,其次是罗登·迈克尔,彼得森·KF共同拥有最多的被引次数。《糖尿病》发表了关于该主题研究的最多文章,其次是《美国生理学杂志 - 内分泌与代谢》《糖尿病学》。该主题的要点是线粒体与2型糖尿病之间的关系、2型糖尿病中观察到的骨骼肌线粒体变化以及线粒体功能障碍对2型糖尿病的影响。在过去五年中,颗粒动力学、线粒体功能障碍和机制研究已成为该领域的重要焦点。

结论

本文成功确定了线粒体与2型糖尿病关系中的关键领域和新出现的趋势,从而为未来研究提供了有价值的见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cba7/11614640/5f39d45faadd/fendo-15-1474232-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cba7/11614640/d11fac290985/fendo-15-1474232-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cba7/11614640/5f39d45faadd/fendo-15-1474232-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cba7/11614640/d11fac290985/fendo-15-1474232-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cba7/11614640/e2f1239b9b37/fendo-15-1474232-g002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cba7/11614640/b8ee346b0702/fendo-15-1474232-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cba7/11614640/0df296f42e86/fendo-15-1474232-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cba7/11614640/5f39d45faadd/fendo-15-1474232-g008.jpg

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本文引用的文献

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Signal Transduct Target Ther. 2024 Oct 2;9(1):262. doi: 10.1038/s41392-024-01951-9.
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Comparative Determination of Mitochondrial Biomarkers and Their Relationship With Insulin Resistance in Type 2 Diabetic Patients: An Observational Cross-Sectional Study.
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Nuclear Nicotinamide Adenine Dinucleotide Deficiency by Nmnat1 Deletion Impaired Hepatic Insulin Signaling, Mitochondrial Function, and Hepatokine Expression in Mice Fed a High-Fat Diet.Nmnat1 缺失导致的核烟酰胺腺嘌呤二核苷酸缺乏症损害了高脂肪饮食喂养小鼠的肝胰岛素信号、线粒体功能和肝分泌因子表达。
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