Clinical School of the Second People's Hospital, Tianjin Medical University, Tianjin, China.
Department of Hepatology, Tianjin Second People's Hospital, Tianjin, China.
Immun Inflamm Dis. 2024 Mar;12(3):e1226. doi: 10.1002/iid3.1226.
Nonalcoholic fatty liver disease (NAFLD) has garnered significant attention in the past decade as a prevalent chronic liver condition. Despite a growing body of evidence implicating mitochondria in NAFLD development, comprehensive bibliometric analyses within this research domain are scarce. This study aims to provide a thorough overview of the knowledge framework and key research areas related to mitochondria in the context of NAFLD, utilizing bibliometric techniques.
A comprehensive search of publications on mitochondria in NAFLD from 2000 to 2023 was conducted using the Web of Science Core Collection database. VOSviewers, CiteSpace, and the R package "bibliometrix" were employed for a precise assessment of the literature.
Examining 2530 articles from 77 countries, primarily led by the United States and China, revealed a consistent increase in publications on mitochondria's role in NAFLD. Leading research institutions include the University of Coimbra, the University of Missouri, the Chinese Academy of Sciences, Fudan University, and Shanghai Jiao Tong University. Notably, the International Journal of Molecular Sciences emerged as the most popular journal, and Hepatology was the most frequently cited. With contributions from 14,543 authors, Michael Roden published the highest number of papers, and A. J. Samyal was the most frequently cocited author. Key focus areas include investigating mitochondrial mechanisms impacting NAFLD and developing therapeutic strategies targeting mitochondria. Emerging research hotspots are associated with keywords such as "inflammation," "mitochondrial dysfunction," "autophagy," "obesity," and "insulin resistance."
This study, the first comprehensive bibliometric analysis, synthesizes research trends and advancements in the role of mitochondria in NAFLD. Insights derived from this analysis illuminate current frontiers and emerging areas of interest, providing a valuable reference for scholars dedicated to mitochondrial studies.
非酒精性脂肪性肝病 (NAFLD) 在过去十年中受到了极大关注，成为一种普遍的慢性肝病。尽管越来越多的证据表明线粒体与 NAFLD 的发展有关，但在这一研究领域中，全面的文献计量分析仍然很少。本研究旨在利用文献计量学技术，全面概述与 NAFLD 相关的线粒体的知识框架和主要研究领域。
使用 Web of Science 核心合集数据库对 2000 年至 2023 年期间 NAFLD 中关于线粒体的出版物进行了全面检索。VOSviewer、CiteSpace 和 R 包“bibliometrix”用于对文献进行精确评估。
从 77 个国家/地区的 2530 篇文章中发现，主要由美国和中国领导的研究表明，关于线粒体在 NAFLD 中的作用的出版物持续增加。主要的研究机构包括科英布拉大学、密苏里大学、中国科学院、复旦大学和上海交通大学。值得注意的是，《国际分子科学杂志》成为最受欢迎的期刊，《肝脏病学》是被引频次最高的期刊。有 14543 名作者参与，Michael Roden 发表的论文数量最多，A. J. Samyal 是被引频次最高的作者。主要的重点领域包括研究影响 NAFLD 的线粒体机制和开发针对线粒体的治疗策略。新兴的研究热点与“炎症”、“线粒体功能障碍”、“自噬”、“肥胖”和“胰岛素抵抗”等关键词相关。
这是第一项全面的文献计量分析研究，综合了线粒体在 NAFLD 中的作用的研究趋势和进展。从这项分析中获得的见解阐明了当前的前沿和新兴的兴趣领域，为致力于线粒体研究的学者提供了有价值的参考。
