Gao Hanwei, Chen Zhongyu, Yao Yutong, He Yuquan, Hu Xin
Department of Cardiology, China-Japan Union Hospital of Jilin University, Jilin University, Changchun, Jilin, China.
CJUH-JLU-China iGEM Team, Jilin University, Changchun, Jilin, China.
Front Oncol. 2024 Nov 20;14:1453090. doi: 10.3389/fonc.2024.1453090. eCollection 2024.
Cancer and cardiovascular disease (CVD) are leading causes of mortality and thus represent major health challenges worldwide. Clinical data suggest that cancer patients have an increased likelihood of developing cardiovascular disease, while epidemiologic studies have shown that patients with cardiovascular disease are also more likely to develop cancer. These observations underscore the increasing importance of studies exploring the mechanisms underlying the interaction between the two diseases. We review their common physiological processes and potential pathophysiological links. We explore the effects of chronic inflammation, oxidative stress, and disorders of fatty acid metabolism in CVD and cancer, and also provide insights into how cancer and its treatments affect heart health, as well as present recent advances in reverse cardio-oncology using a new classification approach.
癌症和心血管疾病（CVD）是导致死亡的主要原因，因此是全球主要的健康挑战。临床数据表明，癌症患者患心血管疾病的可能性增加，而流行病学研究表明，心血管疾病患者也更有可能患癌症。这些观察结果突显了探索这两种疾病之间相互作用潜在机制的研究的重要性日益增加。我们综述了它们共同的生理过程和潜在的病理生理联系。我们探讨了慢性炎症、氧化应激和脂肪酸代谢紊乱在心血管疾病和癌症中的作用，还深入了解了癌症及其治疗如何影响心脏健康，并使用一种新的分类方法介绍了反向心脏肿瘤学的最新进展。
