Department of Cardiology, MKCG Medical College and Hospital, Berhampur, Odisha, India.
Department of Cardiology, MKCG Medical College and Hospital, Berhampur, Odisha, India.
Indian Heart J. 2023 Nov-Dec;75(6):398-402. doi: 10.1016/j.ihj.2023.09.004. Epub 2023 Sep 27.
Having established the significance of cardiovascular side-effects of anti-neoplastic drugs, present day cardio-oncology has forayed into newer territories buoyed by research into the multiple connections that exist between cardiovascular disease and cancer. An emerging concept of reverse cardio-oncology focuses on the heightened risk of cancer in patients with cardiovascular disease. Common mechanistics of cancer and heart failure (HF) like chronic inflammation and clonal haematopoesis as well as common predisposing factors like obesity and diabetes underline the relation between both cardiovascular disease and various cancers.This review discusses the potential magnitude of the problem, the underlying pathophysiological mechanisms and classification of this novel subject.
在确定了抗肿瘤药物的心血管副作用的重要性之后，当今的肿瘤心脏病学在研究心血管疾病与癌症之间存在的多种联系的推动下，已经进入了新的领域。一个新兴的逆向肿瘤心脏病学概念侧重于关注心血管疾病患者的癌症风险升高。癌症和心力衰竭（HF）的共同发病机制，如慢性炎症和克隆性造血，以及肥胖和糖尿病等常见的诱发因素，强调了心血管疾病与各种癌症之间的关系。本文讨论了这个新课题的潜在问题的严重程度、潜在的病理生理机制和分类。
