Roelofs Eline F, Bas-Hoogendam Janna Marie, Winkler Anderson M, van der Wee Nic J A, Vermeiren Robert R J M
LUMC-Curium, Department of Child and Adolescent Psychiatry, Leiden University Medical Center, Leiden, the Netherlands.
Department of Psychiatry, Leiden University Medical Center, Leiden, the Netherlands.
Neurosci Appl. 2024;3. doi: 10.1016/j.nsa.2024.104090. Epub 2024 Sep 24.
Longitudinal studies using resting-state functional magnetic resonance imaging (rs-fMRI) focused on adolescent internalizing psychopathology are scarce and have mostly investigated standardized treatment effects on functional connectivity (FC) of the full amygdala. The role of amygdala subregions and large resting-state networks had yet to be elucidated, and treatment is in practice often personalized. Here, longitudinal FC development of amygdala subregions and whole-brain networks are investigated in a clinically representative sample. Treatment-naïve adolescents with clinical depression and comorbid anxiety who started care-as-usual (n = 23; INT) and healthy controls (n = 24; HC) participated in rs-fMRI scans and questionnaires at baseline (before treatment) and after three months. Changes between and within groups over time in FC of the laterobasal amygdala (LBA), centromedial amygdala (CMA) and whole-brain networks derived from independent component analysis (ICA) were investigated. Groups differed significantly in FC development of the right LBA to the postcentral gyrus and the left LBA to the frontal pole. Within INT, FC to the frontal pole and postcentral gyrus changed over time while changes in FC of the right LBA were also linked to symptom change. No significant interactions were observed when considering FC from CMA bilateral seeds or within ICA-derived networks. Results in this cohort suggest divergent longitudinal development of FC from bilateral LBA subregions in adolescents with internalizing disorders compared to healthy peers, possibly reflecting nonspecific treatment effects. Moreover, associations were found with symptom change. These results highlight the importance of differentiation of amygdala subregions in neuroimaging research in adolescents.
使用静息态功能磁共振成像（rs-fMRI）针对青少年内化性精神病理学进行的纵向研究很少，并且大多研究了标准化治疗对整个杏仁核功能连接（FC）的影响。杏仁核亚区域和大型静息态网络的作用尚未阐明，而在实际治疗中通常是个性化的。在此，我们在一个具有临床代表性的样本中研究了杏仁核亚区域和全脑网络的纵向FC发展。未接受过治疗的患有临床抑郁症和共病焦虑症的青少年开始接受常规护理（n = 23；INT组），健康对照组（n = 24；HC组）在基线（治疗前）和三个月后参与了rs-fMRI扫描和问卷调查。研究了外侧基底杏仁核（LBA）、中央内侧杏仁核（CMA）以及源自独立成分分析（ICA）的全脑网络的FC随时间在组间和组内的变化。在右侧LBA与中央后回以及左侧LBA与额极的FC发展方面，两组存在显著差异。在INT组中，与额极和中央后回的FC随时间发生变化，而右侧LBA的FC变化也与症状变化相关。当考虑来自双侧CMA种子或ICA衍生网络内的FC时，未观察到显著的相互作用。该队列研究结果表明，与健康同龄人相比，患有内化性障碍的青少年双侧LBA亚区域的FC纵向发展存在差异，这可能反映了非特异性治疗效果。此外，还发现了与症状变化的关联。这些结果凸显了在青少年神经影像学研究中区分杏仁核亚区域的重要性。
