Chen Xiao, Ma Xiaopeng, Yang Gui, Huang Guan, Dai Haibing, Liu Nian, Yu Jianbo
Longgang Central Hospital of Shenzhen, Shenzhen 518116, China.
School of Control Science and Engineering, Shandong University, Jinan 250061, China.
Nanophotonics. 2023 Aug 23;12(18):3645-3652. doi: 10.1515/nanoph-2023-0358. eCollection 2023 Sep.
The unique optical properties of squaraine dyes make them promising for cancer phototheranostics, but the reported squaraines for treatments mainly rely on their photothermal effect, where monotherapy cannot achieve the desired therapeutic effect. Here we generated a type of squaraine capable of killing tumors through both photothermal and photodynamic effects. We optimized squaraine structure with selenium modulation and formulated it into nanoparticles that showed strong absorption of infrared light, negligible fluorescence, good photothermal conversion (66.6 %), and strong photodynamic effects even after several irradiation cycles. In addition, the nanoparticles could be tracked through their strong optoacoustic signal. In mice, the nanoparticles effectively accumulated in tumors and eliminated them upon irradiation, without causing adverse effects. Our work demonstrates the potential of selenium modulation of squaraine for precise cancer diagnosis and treatment through synergistic photothermal and photodynamic effects.
方酸菁染料独特的光学性质使其在癌症光诊疗方面具有潜力，但报道的用于治疗的方酸菁主要依赖其光热效应，单一疗法无法达到理想的治疗效果。在此，我们制备了一种能够通过光热和光动力效应杀死肿瘤的方酸菁。我们通过硒调制优化了方酸菁结构，并将其制成纳米颗粒，该纳米颗粒对红外光有强烈吸收、荧光可忽略不计、具有良好的光热转换效率（66.6%），且即使经过多次照射循环仍具有很强的光动力效应。此外，纳米颗粒可通过其强烈的光声信号进行追踪。在小鼠体内，纳米颗粒有效地在肿瘤中蓄积，并在照射后消除肿瘤，且未引起不良反应。我们的工作证明了通过硒调制方酸菁，利用协同的光热和光动力效应进行精确癌症诊断和治疗的潜力。
