免疫反应在肺炎中起作用。
Immune response plays a role in pneumonia.
机构信息
Department of Respiratory Medicine, Children's Hospital of Nanjing Medical University, Nanjing, China.
Department of Respiratory Medicine, The Affiliated Wuxi Children's Hospital of Nanjing Medical University, Wuxi, China.
出版信息
Front Immunol. 2023 May 26;14:1189647. doi: 10.3389/fimmu.2023.1189647. eCollection 2023.
INTRODUCTION
Mycoplasma pneumoniae (MP) is a major pathogen of community-acquired pneumonia in children. However, the specific pathogenesis of the progression of Mycoplasma pneumoniae pneumonia (MPP) is unclear. We aimed to reveal the landscape of microbiota and the host immune response in MPP.
METHODS
This self-controlled study analyzed the microbiome and transcriptome of bronchoalveolar lavage fluid (BALF) from the severe side (SD) and opposite side (OD) of 41 children with MPP from January to December 2021 and revealed the differences of the peripheral blood neutrophil function among children with mild MPP, severe MPP, and healthy children through transcriptome sequencing.
RESULTS
The MP load or the pulmonary microbiota had no significant difference between the SD group and OD group, and the deterioration of MPP was related to the immune response, especially the intrinsic immune response.
DISCUSSION
The immune response plays a role in MPP, which may inform treatment strategies for MPP.
简介
肺炎支原体（MP）是儿童社区获得性肺炎的主要病原体。然而，肺炎支原体肺炎（MPP）进展的具体发病机制尚不清楚。本研究旨在揭示 MPP 中微生物组和宿主免疫反应的全貌。
方法
本自对照研究分析了 2021 年 1 月至 12 月期间 41 例 MPP 患儿严重侧（SD）和对侧（OD）支气管肺泡灌洗液（BALF）的微生物组和转录组，并通过转录组测序揭示了轻症 MPP、重症 MPP 和健康儿童外周血中性粒细胞功能的差异。
结果
MP 负荷或肺部微生物组在 SD 组和 OD 组之间无显著差异，MPP 的恶化与免疫反应有关，特别是固有免疫反应。
讨论
免疫反应在 MPP 中起作用，这可能为 MPP 的治疗策略提供信息。
Zotero 插件