Conoan Nieves Nico E, Widom Julia R
University of Oregon Department of Chemistry and Biochemistry, Eugene, USA.
Chem Commun (Camb). 2024 Dec 19;61(2):346-349. doi: 10.1039/d4cc04261a.
The Class II NAD riboswitch is a bacterial RNA that binds ligands containing nicotinamide. Herein, we report a fluorescence and biolayer interferometry study of riboswitch interactions with β-NMN. The results reveal a shift in the prevalence of a pseudoknot structure in the presence of ligand and Mg.
II类烟酰胺腺嘌呤二核苷酸核糖开关是一种结合含烟酰胺配体的细菌RNA。在此，我们报告了核糖开关与β-烟酰胺单核苷酸相互作用的荧光和生物层干涉术研究。结果揭示了在配体和镁存在的情况下假结结构发生率的变化。
