用于苏木精-伊红（H&E）组织学和多重免疫荧光的自发荧光虚拟染色系统在肺癌免疫肿瘤生物标志物中的应用
Autofluorescence Virtual Staining System for H&E Histology and Multiplex Immunofluorescence Applied to Immuno-Oncology Biomarkers in Lung Cancer.
作者信息
Loo Jessica, Robbins Marc, McNeil Carson, Yoshitake Tadayuki, Santori Charles, Shan Chuanhe Jay, Vyawahare Saurabh, Patel Hardik, Wang Tzu Chien, Findlater Robert, Steiner David F, Rao Sudha, Gutierrez Michael, Wang Yang, Sanchez Adrian C, Yin Raymund, Velez Vanessa, Sigman Julia S, Coutinho de Souza Patricia, Chandrupatla Hareesh, Scott Liam, Weaver Shamira S, Lee Chung-Wein, Rivlin Ehud, Goldenberg Roman, Couto Suzana S, Cimermancic Peter, Wong Pok Fai
机构信息
Verily, South San Francisco, California.
Google, Mountain View, California.
出版信息
Cancer Res Commun. 2025 Jan 1;5(1):54-65. doi: 10.1158/2767-9764.CRC-24-0327.
We extend the capabilities of virtual staining from AF to a different disease and stain modality. Our work includes newly developed virtual stains for H&E and a multiplex immunofluorescence panel (DAPI, PanCK, PD-L1, CD3, and CD8) for non-small cell lung cancer, which reproduce the key features of real stains.
我们将虚拟染色的功能从自动荧光（AF）扩展到另一种疾病和染色方式。我们的工作包括新开发的苏木精和伊红（H&E）虚拟染色以及用于非小细胞肺癌的多重免疫荧光面板（4',6-二脒基-2-苯基吲哚（DAPI）、细胞角蛋白（PanCK）、程序性死亡配体1（PD-L1）、CD3和CD8），这些虚拟染色再现了真实染色的关键特征。
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