Xu Liangliang, Li Bo, Liu Yuchen, Hu Zhengming, Dan Qing, Xu Bingxuan, Xiang Hongjin, Chen Yun, Zheng Tingting, Sun Desheng, Liu Li
Shenzhen Key Laboratory for Drug Addiction and Medication Safety, Department of Ultrasound, Institute of Ultrasonic Medicine, Peking University Shenzhen Hospital, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, Shenzhen 518036, China China.
Department of Clinical Oncology, The University of Hong Kong-Shenzhen Hospital, Shenzhen 518053, China.
Aging (Albany NY). 2024 Dec 4;16(22):13608-13626. doi: 10.18632/aging.206167.
Age-related cancers are characterized by impaired protein homeostasis, where Kelch protein superfamily members have showed accumulating clues as critical regulators. In this paper, the cancerous role of Kelch-like family member 23 (KLHL23) was comprehensively analyzed with TCGA and single cell GEO database across overall 33 cancer types. By multi-omics analysis upon the transcriptomic, genomic, and methylation data, the current study explored the association of KLHL23 with patient survival, gene ontology, tumor-infiltrating lymphocytes, and drug responses. The correlation of copy number variations and methylation with dysregulated expression of KLHL23 were also addressed. Notably, KLHL23 levels correlated with survival in cancers such as hepatocellular carcinoma and low-grade glioma. The study also highlighted how reduced KLHL23 expression is linked to increased immune activity and sensitivity to chemotherapy, suggesting its potential as a biomarker for cancer prognosis and treatment responsiveness.
与年龄相关的癌症的特征是蛋白质稳态受损，其中 Kelch 蛋白超家族成员已显示出作为关键调节因子的越来越多的线索。在本文中，利用 TCGA 和单细胞 GEO 数据库对总共 33 种癌症类型全面分析了 Kelch 样家族成员 23（KLHL23）的致癌作用。通过对转录组学、基因组学和甲基化数据的多组学分析，本研究探索了 KLHL23 与患者生存、基因本体论、肿瘤浸润淋巴细胞和药物反应之间的关联。还探讨了拷贝数变异和甲基化与 KLHL23 表达失调的相关性。值得注意的是，KLHL23 水平与肝细胞癌和低级别胶质瘤等癌症的生存相关。该研究还强调了 KLHL23 表达降低如何与免疫活性增加和化疗敏感性相关联，表明其作为癌症预后和治疗反应生物标志物的潜力。
