Szanto David, Wall Michael, Chong Luke X, Kupersmith Mark J
Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, IA, USA.
Transl Vis Sci Technol. 2024 Dec 2;13(12):8. doi: 10.1167/tvst.13.12.8.
Standard automated perimetry (SAP) visual field (VF) results are more repeatable using Goldmann stimulus size V (size V) in eyes with moderate/severe deficits due to glaucoma. There are few reports relating VFs using stimulus size V and III, typically used in the clinic for glaucoma, and none for non-arteritic anterior ischemic optic neuropathy (NAION). We hypothesized that we could compare and relate the VFs with both stimuli for glaucoma and NAION.
We utilized 1992 same-day pairs of size III and size V SAP VFs using the 24-2 strategy for eyes with glaucoma or NAION. We explored the optimal threshold to censor the raw sensitivities, prior to calculating age-standardized total deviations (TDs). We determined the mean and standard deviation of the differences among all TD pairs. We computed a line of best fit to determine closeness to the line of unity.
The ideal censoring conversion threshold was 21 decibel (dB) for size III and 24 dB for size V. The difference between size V and size III censored (0.0 ± 1.9 dB) and uncensored (0.4 ± 2.6 dB) TD pairings highly correlate with each other (r2 = 0.70, P < 0.001). The line of best fit from these pairings has a slope of 0.92, which is close to that of the line of unity (m = 1).
Censoring plus age correction is a valid method of comparison between size III and size V SAP VFs with moderate to severe VF loss due to optic nerve disorders.
Size III and size V TDs are comparable in clinical practice.
在因青光眼导致中度/重度视野缺损的眼中，使用戈德曼刺激大小V（V型）进行标准自动视野计（SAP）视野检查（VF）结果的重复性更高。关于临床上常用于青光眼检查的刺激大小V和III的视野检查报告较少，而对于非动脉炎性前部缺血性视神经病变（NAION）则尚无相关报告。我们推测，对于青光眼和NAION，我们可以比较并关联这两种刺激下的视野检查结果。
我们对患有青光眼或NAION的眼睛采用24-2策略，利用了1992对同一天进行的刺激大小III和V型的SAP视野检查。在计算年龄标准化总偏差（TDs）之前，我们探索了用于审查原始敏感度的最佳阈值。我们确定了所有TD对之间差异的均值和标准差。我们计算了最佳拟合线以确定与统一线的接近程度。
刺激大小III的理想审查转换阈值为21分贝（dB），刺激大小V为24 dB。审查后的刺激大小V和III之间的差异（0.0±1.9 dB）与未审查的差异（0.4±2.6 dB）高度相关（r2 = 0.70，P < 0.001）。这些配对的最佳拟合线斜率为0.92，接近统一线的斜率（m = 1）。
审查加上年龄校正，是比较因视神经疾病导致中度至重度视野缺损的刺激大小III和V型SAP视野检查结果的有效方法。
在临床实践中，刺激大小III和V的TDs具有可比性。
