Szanto David, Wall Michael, Chong Luke X, Woods Brian, Elze Tobias, Wang Jui-Kai, Garvin Mona, Kardon Randy, Kupersmith Mark J
Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, IA, USA.
Transl Vis Sci Technol. 2024 Dec 2;13(12):15. doi: 10.1167/tvst.13.12.15.
Disorders of the anterior optic nerve cause quantifiable patterns, or archetypes (AT), in visual fields (VFs) obtained using standardized automated perimetry using stimulus size III (size III). VFs with stimulus size V (size V) can reduce retest variability in eyes with moderate to severe loss. We postulated that VF testing using both stimuli would show similar ATs in eyes with glaucoma and nonarteritic anterior ischemic optic neuropathy (NAION).
We used 1969 same-day pairs of 24-2 size III and size V VFs from two datasets. QRK207 is the largest NAION study to date, and the VIPII study measured same-day VFs across many stimulus sizes. We censored raw sensitivities of less than 21 dB for size III and 24 dB for size V and age-standardized to total deviations, before archetypal analysis (AA). We compared the ATs between the two stimuli and the combined data.
Using 14 ATs for both glaucoma and NAION, AA captured similar patterns between the two stimuli in both diseases with 87% of AT pairings having a cosine similarity of 0.8 or greater. The combined ATs retained the patterns in the separate stimuli VFs.
AA shows that size V VFs provide quantifiable patterns of loss similar to size III. This aids in comparing stimulus sizes for monitoring VF patterns in disease progression.
AA shows similar quantifiable patterns of VF loss with size III or size V, supporting the use of size V to monitor eyes with moderate to severe VF loss.
前部视神经疾病会在使用III号刺激大小（III型）的标准化自动视野计获得的视野（VF）中产生可量化的模式或原型（AT）。对于中重度视力丧失的眼睛，使用V号刺激大小（V型）的视野检查可减少复测变异性。我们推测，在青光眼和非动脉炎性前部缺血性视神经病变（NAION）患者中，使用这两种刺激进行视野检查会显示出相似的AT。
我们使用了来自两个数据集的1969对同日进行的24-2型III号和V号刺激大小的视野检查数据。QRK207是迄今为止最大的NAION研究，而VIPII研究测量了多种刺激大小的同日视野。在进行原型分析（AA）之前，我们对III号刺激大小小于21 dB和V号刺激大小小于24 dB的原始敏感度进行了审查，并对年龄进行标准化处理，以得到总偏差。我们比较了两种刺激之间以及合并数据的AT。
对于青光眼和NAION，使用14种AT，AA在两种疾病中捕捉到了两种刺激之间的相似模式，87%的AT配对的余弦相似度为0.8或更高。合并后的AT保留了单独刺激视野中的模式。
AA表明，V号刺激大小的视野提供了与III号刺激大小相似的可量化的视野缺损模式。这有助于比较不同刺激大小，以监测疾病进展中的视野模式。
AA显示III号或V号刺激大小的视野缺损具有相似的可量化模式，支持使用V号刺激大小来监测中重度视野缺损的眼睛。
