Chang Wei-Chih, Kudlacek Jan, Jiruska Premysl, Jefferys John G. R.
The cellular and network mechanisms of seizure emergence (ictogenesis) remain unknown. Recent studies brought new fundamental insights about the complex nature of seizure genesis and the dynamical principles that govern the shift of epileptic networks dynamics into the seizure state. In this chapter, we describe new perspectives on how to approach understanding ictogenesis. Primarily, we focus on the latest data about the dynamical pathways and pathophysiological processes that drive the transition to seizure. In addition, we review recent evidence about the existence of long-term fluctuations in seizure likelihood which represent a missing piece in the mosaic of ictogenesis. We demonstrate that combining the cellular and network mechanisms at multiple temporal scales (ranging from epileptogenesis to seizure initiation) is a crucial step to a unified theory of seizure genesis.
癫痫发作起始（致痫过程）的细胞和网络机制仍不清楚。最近的研究为癫痫发作起源的复杂本质以及控制癫痫网络动力学转变为发作状态的动力学原理带来了新的基本见解。在本章中，我们描述了关于如何理解致痫过程的新观点。首先，我们关注有关驱动向癫痫发作转变的动力学途径和病理生理过程的最新数据。此外，我们回顾了最近关于癫痫发作可能性存在长期波动的证据，这是致痫过程拼图中缺失的一块。我们证明，在多个时间尺度（从癫痫发生到发作起始）上结合细胞和网络机制是建立癫痫发作起源统一理论的关键一步。
