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尽管兔体内存在抗半乳糖脑苷脂循环抗体,但再生的周围神经芽仍能正常髓鞘化。

Normal myelination of regenerating peripheral nerve sprouts despite circulating antibodies to galactocerebroside in rabbits.

作者信息

Stoll G, Reiners K, Schwendemann G, Heininger K, Toyka K V

出版信息

Ann Neurol. 1986 Feb;19(2):189-92. doi: 10.1002/ana.410190213.

DOI:10.1002/ana.410190213
PMID:3963761
Abstract

Rabbits were immunized with galactocerebroside and a crush lesion was created in the tibial nerve before the onset of experimental allergic neuritis. Normal regeneration and myelination of distal peripheral nerve sprouts occurred and was identical to that of controls, although circulating antigalactocerebroside antibodies were present and nerve roots showed typical signs of beginning experimental allergic neuritis.

摘要

用半乳糖脑苷脂对兔子进行免疫,在实验性变应性神经炎发作前,在胫神经上造成挤压损伤。尽管存在循环抗半乳糖脑苷脂抗体,且神经根显示出开始发生实验性变应性神经炎的典型迹象,但远端周围神经芽正常再生和髓鞘形成,且与对照组相同。

相似文献

1
Normal myelination of regenerating peripheral nerve sprouts despite circulating antibodies to galactocerebroside in rabbits.尽管兔体内存在抗半乳糖脑苷脂循环抗体,但再生的周围神经芽仍能正常髓鞘化。
Ann Neurol. 1986 Feb;19(2):189-92. doi: 10.1002/ana.410190213.
2
Anti-galactocerebroside antibody in rabbits with experimental allergic neuritis.实验性变应性神经炎兔体内的抗半乳糖脑苷脂抗体
Jpn J Exp Med. 1986 Apr;56(2):43-9.
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Relation of clinical, serological, morphological, and electrophysiological findings in galactocerebroside-induced experimental allergic neuritis.半乳糖脑苷脂诱导的实验性变应性神经炎中临床、血清学、形态学及电生理学检查结果的关系
J Neurol Neurosurg Psychiatry. 1986 Mar;49(3):258-64. doi: 10.1136/jnnp.49.3.258.
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Experimental allergic neuritis induced by sensitization with galactocerebroside.用半乳糖脑苷脂致敏诱导的实验性变应性神经炎。
Science. 1979 Jun 8;204(4397):1103-6. doi: 10.1126/science.451555.
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Experimental allergic neuritis induced by galactocerebroside.由半乳糖脑苷脂诱导的实验性变应性神经炎。
Ann Neurol. 1981;9 Suppl:87-101. doi: 10.1002/ana.410090714.
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[Micromethod of determining antibodies to nerve tissue galactocerebrosides in the complement fixation reaction].[补体结合反应中神经组织半乳糖脑苷脂抗体的微量测定方法]
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Experimental allergic neuritis: demyelination induced by P2 alone and non-specific enhancement by cerebroside.实验性变应性神经炎:单独由P2诱导的脱髓鞘以及脑苷脂的非特异性增强作用。
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Antigenicity of galactocerebroside in experimental allergic demyelinating diseases.半乳糖脑苷脂在实验性变应性脱髓鞘疾病中的抗原性
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Lab Invest. 1986 Jul;55(1):86-90.

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Nerve injury, axonal degeneration and neural regeneration: basic insights.神经损伤、轴突退变与神经再生:基础见解
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