Stoll G, Schwendemann G, Heininger K, Köhne W, Hartung H P, Seitz R, Toyka K V
J Neurol Neurosurg Psychiatry. 1986 Mar;49(3):258-64. doi: 10.1136/jnnp.49.3.258.
Rabbits were immunised repeatedly with bovine brain galactocerebroside. Almost all animals developed overt polyradiculoneuropathy. Circulating IgG antibodies to galactocerebroside in the serum and deposits of IgG in the spinal roots were detectable weeks before definite clinical, morphological, and electrophysiological alterations occurred. The levels of IgG antibody titres to galactocerebroside did not correlate with the severity of the clinical disease and of nerve conduction slowing. Remyelination and a virtually complete recovery of nerve dysfunction occurred although circulating antibodies to galactocerebroside were still present.
用牛脑半乳糖脑苷脂反复免疫兔子。几乎所有动物都出现了明显的多神经根神经病。在明确的临床、形态学和电生理改变出现前数周，就能检测到血清中针对半乳糖脑苷脂的循环IgG抗体以及脊髓神经根中IgG的沉积。针对半乳糖脑苷脂的IgG抗体滴度水平与临床疾病的严重程度和神经传导减慢情况无关。尽管针对半乳糖脑苷脂的循环抗体仍然存在，但仍发生了髓鞘再生以及神经功能障碍的几乎完全恢复。
